ENSG00000071242


Homo sapiens

Features
Gene ID: ENSG00000071242
  
Biological name :RPS6KA2
  
Synonyms : Q15349 / ribosomal protein S6 kinase A2 / RPS6KA2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q27
Gene start: 166409364
Gene end: 166906451
  
Corresponding Affymetrix probe sets: 1557970_s_at (Human Genome U133 Plus 2.0 Array)   204906_at (Human Genome U133 Plus 2.0 Array)   212912_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422197
Ensembl peptide - ENSP00000422435
Ensembl peptide - ENSP00000427605
Ensembl peptide - ENSP00000427015
Ensembl peptide - ENSP00000425458
Ensembl peptide - ENSP00000425148
Ensembl peptide - ENSP00000423114
Ensembl peptide - ENSP00000422484
Ensembl peptide - ENSP00000265678
Ensembl peptide - ENSP00000386050
NCBI entrez gene - 6196     See in Manteia.
OMIM - 601685
RefSeq - XM_006715549
RefSeq - NM_001006932
RefSeq - NM_001318936
RefSeq - NM_001318937
RefSeq - NM_001318938
RefSeq - NM_021135
RefSeq Peptide - NP_066958
RefSeq Peptide - NP_001305866
RefSeq Peptide - NP_001305867
RefSeq Peptide - NP_001006933
RefSeq Peptide - NP_001305865
swissprot - D6RA62
swissprot - D6R910
swissprot - F2Z2J1
swissprot - B7Z3B5
swissprot - Q15349
swissprot - D6RHW7
swissprot - D6RE03
swissprot - D6RD75
Ensembl - ENSG00000071242
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6ka2ENSDARG00000028469Danio rerio
 RPS6KA2ENSGALG00000011473Gallus gallus
 Q9WUT3ENSMUSG00000023809Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P51812 / RPS6KA3 / ribosomal protein S6 kinase A3ENSG0000017718979
Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1ENSG0000011767676
Q9UK32 / RPS6KA6 / ribosomal protein S6 kinase A6ENSG0000007213372
O75582 / RPS6KA5 / ribosomal protein S6 kinase A5ENSG0000010078441
O75676 / RPS6KA4 / ribosomal protein S6 kinase A4ENSG0000016230240
P23443 / RPS6KB1 / ribosomal protein S6 kinase B1ENSG0000010844329
Q9UBS0 / RPS6KB2 / ribosomal protein S6 kinase B2ENSG0000017563428
Q9NY57 / STK32B / serine/threonine kinase 32BENSG0000015295317
Q86UX6 / STK32C / serine/threonine kinase 32CENSG0000016575217
Q8WU08 / STK32A / serine/threonine kinase 32AENSG0000016930216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0002035 brain renin-angiotensin system IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010659 cardiac muscle cell apoptotic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045835 negative regulation of meiotic nuclear division IEA
 biological_processGO:0060047 heart contraction IEA
 biological_processGO:0070613 regulation of protein processing IEA
 biological_processGO:0071322 cellular response to carbohydrate stimulus IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004711 ribosomal protein S6 kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction
 ENSG00000172216 CEBPB / P17676 / CCAAT/enhancer binding protein beta  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction
 ENSG00000166484 MAPK7 / Q13164 / mitogen-activated protein kinase 7  / reaction






 

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