ENSG00000072133


Homo sapiens

Features
Gene ID: ENSG00000072133
  
Biological name :RPS6KA6
  
Synonyms : Q9UK32 / ribosomal protein S6 kinase A6 / RPS6KA6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q21.1
Gene start: 84058346
Gene end: 84187907
  
Corresponding Affymetrix probe sets: 220737_at (Human Genome U133 Plus 2.0 Array)   220738_s_at (Human Genome U133 Plus 2.0 Array)   228502_at (Human Genome U133 Plus 2.0 Array)   228503_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262752
Ensembl peptide - ENSP00000483896
NCBI entrez gene - 27330     See in Manteia.
OMIM - 300303
RefSeq - XM_017029426
RefSeq - NM_001330512
RefSeq - NM_014496
RefSeq - XM_017029423
RefSeq - XM_017029424
RefSeq - XM_017029425
RefSeq - XM_011530917
RefSeq - XM_011530918
RefSeq - XM_011530919
RefSeq - XM_011530920
RefSeq Peptide - NP_055311
RefSeq Peptide - NP_001317441
swissprot - Q9UK32
Ensembl - ENSG00000072133
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6kalENSDARG00000037574Danio rerio
 RPS6KA6ENSGALG00000007097Gallus gallus
 Rps6ka6ENSMUSG00000025665Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P51812 / RPS6KA3 / ribosomal protein S6 kinase A3ENSG0000017718977
Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2ENSG0000007124274
Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1ENSG0000011767671
O75582 / RPS6KA5 / ribosomal protein S6 kinase A5ENSG0000010078442
O75676 / RPS6KA4 / ribosomal protein S6 kinase A4ENSG0000016230240
P23443 / RPS6KB1 / ribosomal protein S6 kinase B1ENSG0000010844328
Q9UBS0 / RPS6KB2 / ribosomal protein S6 kinase B2ENSG0000017563426
Q86UX6 / STK32C / serine/threonine kinase 32CENSG0000016575218
Q9NY57 / STK32B / serine/threonine kinase 32BENSG0000015295317
Q8WU08 / STK32A / serine/threonine kinase 32AENSG0000016930216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045992 negative regulation of embryonic development ISS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:2000381 negative regulation of mesoderm development ISS
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
RSK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr