ENSMUSG00000025665


Mus musculus

Features
Gene ID: ENSMUSG00000025665
  
Biological name :Rps6ka6
  
Synonyms : ribosomal protein S6 kinase polypeptide 6 / Rps6ka6
  
Possible biological names infered from orthology : Q9UK32 / ribosomal protein S6 kinase A6
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: E1
Gene start: 111388192
Gene end: 111537959
  
Corresponding Affymetrix probe sets: 10606445 (MoGene1.0st)   1429759_at (Mouse Genome 430 2.0 Array)   1429760_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068483
Ensembl peptide - ENSMUSP00000121722
Ensembl peptide - ENSMUSP00000121489
Ensembl peptide - ENSMUSP00000121075
Ensembl peptide - ENSMUSP00000120611
Ensembl peptide - ENSMUSP00000120004
Ensembl peptide - ENSMUSP00000118075
Ensembl peptide - ENSMUSP00000117228
Ensembl peptide - ENSMUSP00000115975
Ensembl peptide - ENSMUSP00000109055
Ensembl peptide - ENSMUSP00000094073
Ensembl peptide - ENSMUSP00000080694
NCBI entrez gene - 67071     See in Manteia.
MGI - MGI:1914321
RefSeq - NM_025949
RefSeq - XM_006528400
RefSeq - XM_006528401
RefSeq - XM_006528402
RefSeq - XM_006528403
RefSeq - XM_006528404
RefSeq - XM_011247706
RefSeq - XM_011247707
RefSeq Peptide - NP_080225
swissprot - A2CEE6
swissprot - E9QK39
swissprot - A2CEE5
swissprot - E9Q3H1
swissprot - E9PUP0
swissprot - B2GVN8
swissprot - B1B0X4
swissprot - B1B0X3
swissprot - B1B0X2
swissprot - B1B0X1
swissprot - A2CEE8
swissprot - A2CEE7
Ensembl - ENSMUSG00000025665
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6kalENSDARG00000037574Danio rerio
 RPS6KA6ENSGALG00000007097Gallus gallus
 Q9UK32ENSG00000072133Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P18654 / Rps6ka3 / ribosomal protein S6 kinase polypeptide 3 / P51812* / ribosomal protein S6 kinase A3*ENSMUSG0000003130965
P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*ENSMUSG0000000364461
Q9WUT3 / Rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*ENSMUSG0000002380961
Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*ENSMUSG0000002118036
Q9Z2B9 / Rps6ka4 / ribosomal protein S6 kinase, polypeptide 4 / O75676* / ribosomal protein S6 kinase A4*ENSMUSG0000002495235
Q8BSK8 / Rps6kb1 / ribosomal protein S6 kinase, polypeptide 1 / P23443* / ribosomal protein S6 kinase B1*ENSMUSG0000002051625
Q9Z1M4 / Rps6kb2 / ribosomal protein S6 kinase, polypeptide 2 / Q9UBS0* / ribosomal protein S6 kinase B2*ENSMUSG0000002483024
Q8QZV4 / Stk32c / Serine/threonine-protein kinase 32C / Q86UX6* / serine/threonine kinase 32C*ENSMUSG0000001598115
Q8BGW6 / Stk32a / Serine/threonine-protein kinase 32A / Q8WU08* / serine/threonine kinase 32A*ENSMUSG0000003995414
Q9JJX8 / Stk32b / Serine/threonine-protein kinase 32B / Q9NY57* / serine/threonine kinase 32B*ENSMUSG0000002912314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
CREB phosphorylation through the activation of Ras
RSK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: T/tbtm
Genetic Background: involves: C57BL/6 * MOL-NIS

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: T/tbtm
Genetic Background: involves: C57BL/6 * MOL-NIS

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: T/tbtm
Genetic Background: involves: C57BL/6 * MOL-NIS

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: T/tbtm
Genetic Background: involves: C57BL/6 * MOL-NIS

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: T/tbtm
Genetic Background: involves: C57BL/6 * MOL-NIS

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: T/tbtm
Genetic Background: involves: C57BL/6 * MOL-NIS

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: T/tbtm
Genetic Background: involves: C57BL/6 * MOL-NIS

 MP:0009331 absent primitive node "absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T/tbtm
Genetic Background: involves: C57BL/6 * MOL-NIS

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T/tbtm
Genetic Background: involves: C57BL/6 * MOL-NIS

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr