ENSMUSG00000024952


Mus musculus

Features
Gene ID: ENSMUSG00000024952
  
Biological name :Rps6ka4
  
Synonyms : Q9Z2B9 / ribosomal protein S6 kinase, polypeptide 4 / Rps6ka4
  
Possible biological names infered from orthology : O75676 / ribosomal protein S6 kinase A4
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 6829085
Gene end: 6840601
  
Corresponding Affymetrix probe sets: 10465427 (MoGene1.0st)   1438243_at (Mouse Genome 430 2.0 Array)   1448498_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025903
Ensembl peptide - ENSMUSP00000131581
NCBI entrez gene - 56613     See in Manteia.
MGI - MGI:1930076
RefSeq - XM_017318262
RefSeq - NM_019924
RefSeq - XM_017318261
RefSeq Peptide - NP_064308
swissprot - Q9Z2B9
Ensembl - ENSMUSG00000024952
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6ka4ENSDARG00000044436Danio rerio
 O75676ENSG00000162302Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*ENSMUSG0000002118064
Q9WUT3 / Rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*ENSMUSG0000002380940
P18654 / Rps6ka3 / ribosomal protein S6 kinase polypeptide 3 / P51812* / ribosomal protein S6 kinase A3*ENSMUSG0000003130940
Rps6ka6 / ribosomal protein S6 kinase polypeptide 6 / Q9UK32* / ribosomal protein S6 kinase A6*ENSMUSG0000002566539
P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*ENSMUSG0000000364439
Q9Z1M4 / Rps6kb2 / ribosomal protein S6 kinase, polypeptide 2 / Q9UBS0* / ribosomal protein S6 kinase B2*ENSMUSG0000002483026
Q8BSK8 / Rps6kb1 / ribosomal protein S6 kinase, polypeptide 1 / P23443* / ribosomal protein S6 kinase B1*ENSMUSG0000002051626
Q8QZV4 / Stk32c / Serine/threonine-protein kinase 32C / Q86UX6* / serine/threonine kinase 32C*ENSMUSG0000001598115
Q9JJX8 / Stk32b / Serine/threonine-protein kinase 32B / Q9NY57* / serine/threonine kinase 32B*ENSMUSG0000002912315
Q8BGW6 / Stk32a / Serine/threonine-protein kinase 32A / Q8WU08* / serine/threonine kinase 32A*ENSMUSG0000003995414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0033129 positive regulation of histone phosphorylation IEA
 biological_processGO:0035066 positive regulation of histone acetylation IEA
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0043987 histone H3-S10 phosphorylation IEA
 biological_processGO:0043988 histone H3-S28 phosphorylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0008594 decreased circulating interleukin-10 level "reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008644 increased circulating interleukin-12a level "increase in the amount in the blood of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008647 increased circulating interleukin-12b level "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0008666 increased interleukin-12a secretion "increase in the production or release of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr