MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
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Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
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MP:0003009 | abnormal cytokine secretion | "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0004753 | abnormal miniature excitatory postsynaptic currents | "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atxn2tm2.1Geno/Atxn2tm2.1Geno Genetic Background: B6.129S2-Atxn2tm2.1Geno
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MP:0004947 | skin inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0005095 | decreased T cell proliferation | "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
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MP:0008235 | increased susceptibility to neuronal excitotoxicity | "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf Genetic Background: B6.129P2-Adora1tm1Bbf
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MP:0008553 | increased circulating tumor necrosis factor level | "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca
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MP:0008594 | decreased circulating interleukin-10 level | "reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008596 | increased circulating interleukin-6 level | "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008644 | increased circulating interleukin-12a level | "increase in the amount in the blood of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008647 | increased circulating interleukin-12b level | "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008661 | decreased interleukin-10 secretion | "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca
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MP:0008666 | increased interleukin-12a secretion | "increase in the production or release of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca
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MP:0008669 | increased interleukin-12b secretion | "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca
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MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca
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MP:0008713 | abnormal cytokine level | "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008735 | increased susceptibility to endotoxin shock | "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0009713 | enhanced conditioned place preference behavior | "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
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MP:0009758 | impaired behavioral response to cocaine | "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
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MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0009936 | abnormal dendritic spine morphology | "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atxn2tm2.1Geno/Atxn2tm2.1Geno Genetic Background: B6.129S2-Atxn2tm2.1Geno
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MP:0011380 | enlarged brain ventricle | "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb] |
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf Genetic Background: B6.129P2-Adora1tm1Bbf
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