ENSMUSG00000023027


Mus musculus

Features
Gene ID: ENSMUSG00000023027
  
Biological name :Atf1
  
Synonyms : Atf1 / Cyclic AMP-dependent transcription factor ATF-1 / P81269
  
Possible biological names infered from orthology : activating transcription factor 1 / P18846
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 100227819
Gene end: 100261244
  
Corresponding Affymetrix probe sets: 10426875 (MoGene1.0st)   1417296_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127969
Ensembl peptide - ENSMUSP00000155718
Ensembl peptide - ENSMUSP00000132907
Ensembl peptide - ENSMUSP00000131278
Ensembl peptide - ENSMUSP00000129833
Ensembl peptide - ENSMUSP00000127985
Ensembl peptide - ENSMUSP00000023769
Ensembl peptide - ENSMUSP00000126491
NCBI entrez gene - 11908     See in Manteia.
MGI - MGI:1298366
RefSeq - XM_006520352
RefSeq - NM_007497
RefSeq - XM_006520351
RefSeq Peptide - NP_031523
swissprot - F6U840
swissprot - E9PZB1
swissprot - E9Q356
swissprot - P81269
swissprot - E9PZ49
swissprot - E9PWM8
swissprot - E9PYW2
Ensembl - ENSMUSG00000023027
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atf1ENSDARG00000044301Danio rerio
 ENSGALG00000033614Gallus gallus
 ATF1ENSG00000123268Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*ENSMUSG0000002595862
Crem / P27699 / cAMP-responsive element modulator / Q03060*ENSMUSG0000006388949


Protein motifs (from Interpro)
Interpro ID Name
 IPR001630  cAMP response element binding (CREB) protein
 IPR003102  Coactivator CBP, pKID
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029825  cAMP-dependent transcription factor ATF1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032025 response to cobalt ion IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:1990590 ATF1-ATF4 transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
CREB phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001694 failure to form egg cylinders "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

 MP:0003695 delayed hatching from the zona pellucida "the embryo takes longer than normal to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021180 Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*  / reaction






 

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