ENSMUSG00000063889


Mus musculus

Features
Gene ID: ENSMUSG00000063889
  
Biological name :Crem
  
Synonyms : cAMP-responsive element modulator / Crem / P27699
  
Possible biological names infered from orthology : Q03060
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 3266048
Gene end: 3337748
  
Corresponding Affymetrix probe sets: 10457205 (MoGene1.0st)   1418322_at (Mouse Genome 430 2.0 Array)   1430598_at (Mouse Genome 430 2.0 Array)   1430847_a_at (Mouse Genome 430 2.0 Array)   1449037_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119353
Ensembl peptide - ENSMUSP00000119194
Ensembl peptide - ENSMUSP00000119638
Ensembl peptide - ENSMUSP00000127353
Ensembl peptide - ENSMUSP00000123515
Ensembl peptide - ENSMUSP00000122557
Ensembl peptide - ENSMUSP00000122282
Ensembl peptide - ENSMUSP00000122241
Ensembl peptide - ENSMUSP00000122179
Ensembl peptide - ENSMUSP00000122123
Ensembl peptide - ENSMUSP00000122051
Ensembl peptide - ENSMUSP00000121541
Ensembl peptide - ENSMUSP00000121388
Ensembl peptide - ENSMUSP00000121352
Ensembl peptide - ENSMUSP00000121233
Ensembl peptide - ENSMUSP00000121210
Ensembl peptide - ENSMUSP00000121118
Ensembl peptide - ENSMUSP00000120557
Ensembl peptide - ENSMUSP00000120349
Ensembl peptide - ENSMUSP00000025069
Ensembl peptide - ENSMUSP00000061925
Ensembl peptide - ENSMUSP00000080780
Ensembl peptide - ENSMUSP00000114280
Ensembl peptide - ENSMUSP00000114780
Ensembl peptide - ENSMUSP00000115336
Ensembl peptide - ENSMUSP00000115363
Ensembl peptide - ENSMUSP00000115423
Ensembl peptide - ENSMUSP00000115471
Ensembl peptide - ENSMUSP00000115938
Ensembl peptide - ENSMUSP00000117438
Ensembl peptide - ENSMUSP00000118128
Ensembl peptide - ENSMUSP00000118267
Ensembl peptide - ENSMUSP00000118578
Ensembl peptide - ENSMUSP00000118649
NCBI entrez gene - 12916     See in Manteia.
MGI - MGI:88495
RefSeq - XM_017317809
RefSeq - NM_001110851
RefSeq - NM_001110852
RefSeq - NM_001110853
RefSeq - NM_001110854
RefSeq - NM_001110855
RefSeq - NM_001110856
RefSeq - NM_001110857
RefSeq - NM_001110858
RefSeq - NM_001110859
RefSeq - NM_001271503
RefSeq - NM_001271504
RefSeq - NM_001271505
RefSeq - NM_001271506
RefSeq - NM_001311066
RefSeq - NM_001311067
RefSeq - NM_013498
RefSeq - XM_006525554
RefSeq - XM_006525555
RefSeq - XM_006525556
RefSeq - XM_006525557
RefSeq - XM_006525558
RefSeq - XM_006525559
RefSeq - XM_006525560
RefSeq - XM_006525561
RefSeq - XM_006525562
RefSeq - XM_006525563
RefSeq - XM_006525564
RefSeq - XM_006525565
RefSeq - XM_006525566
RefSeq - XM_006525567
RefSeq - XM_006525568
RefSeq - XM_006525569
RefSeq - XM_006525570
RefSeq - XM_006525572
RefSeq - XM_006525573
RefSeq - XM_006525574
RefSeq - XM_006525575
RefSeq - XM_006525576
RefSeq - XM_006525578
RefSeq - XM_006525579
RefSeq - XM_006525580
RefSeq - XM_006525582
RefSeq - XM_011246820
RefSeq - XM_011246822
RefSeq - XM_011246823
RefSeq - XM_017317808
RefSeq - NM_001110850
RefSeq Peptide - NP_001104328
RefSeq Peptide - NP_001104329
RefSeq Peptide - NP_001258432
RefSeq Peptide - NP_001258433
RefSeq Peptide - NP_001258434
RefSeq Peptide - NP_001258435
RefSeq Peptide - NP_001297995
RefSeq Peptide - NP_001297996
RefSeq Peptide - NP_038526
RefSeq Peptide - NP_001104324
RefSeq Peptide - NP_001104325
RefSeq Peptide - NP_001104326
RefSeq Peptide - NP_001104327
RefSeq Peptide - NP_001104320
RefSeq Peptide - NP_001104321
RefSeq Peptide - NP_001104322
RefSeq Peptide - NP_001104323
swissprot - F6QKL8
swissprot - F6QWT6
swissprot - F6RB97
swissprot - F6U9F5
swissprot - F6VJ22
swissprot - F6W4F5
swissprot - E9PWV9
swissprot - A0A0R4J1V7
swissprot - P27699
swissprot - Q3TTH6
swissprot - Q9CQ87
swissprot - A0A0R4J1S0
swissprot - F6XRJ7
swissprot - E9PV35
swissprot - D6RG82
swissprot - D6RFR5
swissprot - D3Z7P7
swissprot - D3Z7M6
swissprot - D3Z773
swissprot - D3Z6A5
swissprot - D3Z4K8
swissprot - D3Z326
swissprot - D3Z2U7
swissprot - D3Z0R0
swissprot - D3Z0B6
swissprot - D3Z011
swissprot - D3YXV5
swissprot - D3YVP3
swissprot - F6Q346
Ensembl - ENSMUSG00000063889
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cremaENSDARG00000023217Danio rerio
 CREMENSGALG00000007082Gallus gallus
 CREMENSG00000095794Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*ENSMUSG0000002595857
Atf1 / P81269 / Cyclic AMP-dependent transcription factor ATF-1 / P18846* / activating transcription factor 1*ENSMUSG0000002302737


Protein motifs (from Interpro)
Interpro ID Name
 IPR001630  cAMP response element binding (CREB) protein
 IPR003102  Coactivator CBP, pKID
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006687 glycosphingolipid metabolic process IMP
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048384 retinoic acid receptor signaling pathway IEA
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Ptpn6m2Btlr/Ptpn6m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan
Genetic Background: involves: 129 * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan
Genetic Background: involves: 129 * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan
Genetic Background: involves: 129 * C57BL/6

 MP:0001499 kindling "long-lasting epileptogenic changes induced by daily sub threshold electrical brain stimulation, induced model for epilepsy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45446]
Show

Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan
Genetic Background: involves: 129 * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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