ENSMUSG00000024830


Mus musculus

Features
Gene ID: ENSMUSG00000024830
  
Biological name :Rps6kb2
  
Synonyms : Q9Z1M4 / ribosomal protein S6 kinase, polypeptide 2 / Rps6kb2
  
Possible biological names infered from orthology : Q9UBS0 / ribosomal protein S6 kinase B2
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4156713
Gene end: 4163354
  
Corresponding Affymetrix probe sets: 10464618 (MoGene1.0st)   1422268_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116744
Ensembl peptide - ENSMUSP00000123376
Ensembl peptide - ENSMUSP00000117446
Ensembl peptide - ENSMUSP00000025749
Ensembl peptide - ENSMUSP00000112512
NCBI entrez gene - 58988     See in Manteia.
MGI - MGI:1927343
RefSeq - XM_006531812
RefSeq - XM_006531813
RefSeq - XM_006531814
RefSeq - XM_017318266
RefSeq - XM_017318267
RefSeq - NM_021485
RefSeq Peptide - NP_067460
swissprot - Q9Z1M4
swissprot - D6RH86
swissprot - D3YWB8
swissprot - Q80X26
swissprot - E9PUN3
Ensembl - ENSMUSG00000024830
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9UBS0ENSG00000175634Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BSK8 / Rps6kb1 / ribosomal protein S6 kinase, polypeptide 1 / P23443* / ribosomal protein S6 kinase B1*ENSMUSG0000002051670
P18654 / Rps6ka3 / ribosomal protein S6 kinase polypeptide 3 / P51812* / ribosomal protein S6 kinase A3*ENSMUSG0000003130944
P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*ENSMUSG0000000364442
Rps6ka6 / ribosomal protein S6 kinase polypeptide 6 / Q9UK32* / ribosomal protein S6 kinase A6*ENSMUSG0000002566542
Q9WUT3 / Rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*ENSMUSG0000002380941
Q9Z2B9 / Rps6ka4 / ribosomal protein S6 kinase, polypeptide 4 / O75676* / ribosomal protein S6 kinase A4*ENSMUSG0000002495241
Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*ENSMUSG0000002118041
Q8QZV4 / Stk32c / Serine/threonine-protein kinase 32C / Q86UX6* / serine/threonine kinase 32C*ENSMUSG0000001598125
Q8BGW6 / Stk32a / Serine/threonine-protein kinase 32A / Q8WU08* / serine/threonine kinase 32A*ENSMUSG0000003995423
Q9JJX8 / Stk32b / Serine/threonine-protein kinase 32B / Q9NY57* / serine/threonine kinase 32B*ENSMUSG0000002912321


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016238  Ribosomal protein S6 kinase
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043491 protein kinase B signaling IGI
 biological_processGO:0045948 positive regulation of translational initiation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004711 ribosomal protein S6 kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oxttm3Ljm/Oxttm3Ljm
Genetic Background: either: B6.129S2-Oxttm3Ljm or B6.129S6-Oxttm3Ljm

 MP:0003364 insulinoma "a pancreatic islet beta cell adenoma that secretes excess insulin" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014173 increased fatty acid beta-oxidation "increased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr