ENSG00000175634


Homo sapiens

Features
Gene ID: ENSG00000175634
  
Biological name :RPS6KB2
  
Synonyms : Q9UBS0 / ribosomal protein S6 kinase B2 / RPS6KB2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 67428460
Gene end: 67435408
  
Corresponding Affymetrix probe sets: 203777_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436811
Ensembl peptide - ENSP00000432847
Ensembl peptide - ENSP00000450621
Ensembl peptide - ENSP00000473485
Ensembl peptide - ENSP00000308413
Ensembl peptide - ENSP00000410175
NCBI entrez gene - 6199     See in Manteia.
OMIM - 608939
RefSeq - XM_017018108
RefSeq - NM_003952
RefSeq - XM_005274164
RefSeq - XM_005274165
RefSeq - XM_006718655
RefSeq - XM_006718656
RefSeq - XM_006718657
RefSeq Peptide - NP_003943
swissprot - E9PQF6
swissprot - G3V2F1
swissprot - E9PIP7
swissprot - Q9UBS0
swissprot - R4GN47
Ensembl - ENSG00000175634
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9Z1M4ENSMUSG00000024830Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P23443 / RPS6KB1 / ribosomal protein S6 kinase B1ENSG0000010844371
Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2ENSG0000007124244
P51812 / RPS6KA3 / ribosomal protein S6 kinase A3ENSG0000017718943
Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1ENSG0000011767641
O75582 / RPS6KA5 / ribosomal protein S6 kinase A5ENSG0000010078441
O75676 / RPS6KA4 / ribosomal protein S6 kinase A4ENSG0000016230241
Q9UK32 / RPS6KA6 / ribosomal protein S6 kinase A6ENSG0000007213341
Q86UX6 / STK32C / serine/threonine kinase 32CENSG0000016575225
Q8WU08 / STK32A / serine/threonine kinase 32AENSG0000016930223
Q9NY57 / STK32B / serine/threonine kinase 32BENSG0000015295322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016238  Ribosomal protein S6 kinase
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043491 protein kinase B signaling TAS
 biological_processGO:0045948 positive regulation of translational initiation IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004711 ribosomal protein S6 kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the nucleus
Constitutive Signaling by AKT1 E17K in Cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr