ENSG00000172216


Homo sapiens

Features
Gene ID: ENSG00000172216
  
Biological name :CEBPB
  
Synonyms : CCAAT/enhancer binding protein beta / CEBPB / P17676
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.13
Gene start: 50190734
Gene end: 50192689
  
Corresponding Affymetrix probe sets: 212501_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305422
NCBI entrez gene - 1051     See in Manteia.
OMIM - 189965
RefSeq - NM_005194
RefSeq - NM_001285878
RefSeq - NM_001285879
RefSeq Peptide - NP_001272807
RefSeq Peptide - NP_001272808
RefSeq Peptide - NP_005185
swissprot - P17676
Ensembl - ENSG00000172216
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cebpbENSDARG00000042725Danio rerio
 CEBPBENSGALG00000008014Gallus gallus
 CebpbENSMUSG00000056501Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CEBPA / P49715 / CCAAT/enhancer binding protein alphaENSG0000024584830
CEBPE / Q15744 / CCAAT/enhancer binding protein epsilonENSG0000009206729
CEBPD / P49716 / CCAAT/enhancer binding protein deltaENSG0000022186926
CEBPG / P53567 / CCAAT/enhancer binding protein gammaENSG0000015387914


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR016468  CCAAT/enhancer-binding protein, chordates


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006953 acute-phase response TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007613 memory IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045408 regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045670 regulation of osteoclast differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0060644 mammary gland epithelial cell differentiation IEA
 biological_processGO:0060850 regulation of transcription involved in cell fate commitment IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0072574 hepatocyte proliferation IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1901329 regulation of odontoblast differentiation ISS
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
 cellular_componentGO:0000779 condensed chromosome, centromeric region IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0036488 CHOP-C/EBP complex NAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Senescence-Associated Secretory Phenotype (SASP)
Transcriptional regulation of white adipocyte differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000071242 Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000172216 CEBPB / P17676 / CCAAT/enhancer binding protein beta  / complex / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / reaction / complex
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex / reaction
 ENSG00000117676 Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1  / reaction
 ENSG00000177189 P51812 / RPS6KA3 / ribosomal protein S6 kinase A3  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr