ENSMUSG00000056501


Mus musculus

Features
Gene ID: ENSMUSG00000056501
  
Biological name :Cebpb
  
Synonyms : CCAAT/enhancer-binding protein beta / Cebpb / P28033
  
Possible biological names infered from orthology : P17676
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 167688915
Gene end: 167690418
  
Corresponding Affymetrix probe sets: 10478890 (MoGene1.0st)   1418901_at (Mouse Genome 430 2.0 Array)   1427844_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069850
NCBI entrez gene - 12608     See in Manteia.
MGI - MGI:88373
RefSeq - NM_009883
RefSeq - NM_001287738
RefSeq - NM_001287739
RefSeq Peptide - NP_001274667
RefSeq Peptide - NP_001274668
RefSeq Peptide - NP_034013
swissprot - P28033
swissprot - Q3UPN9
Ensembl - ENSMUSG00000056501
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cebpbENSDARG00000042725Danio rerio
 CEBPBENSGALG00000008014Gallus gallus
 CEBPBENSG00000172216Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cebpa / P53566 / CCAAT/enhancer-binding protein alpha / P49715*ENSMUSG0000003495736
Cebpe / Q6PZD9 / CCAAT/enhancer-binding protein epsilon / Q15744*ENSMUSG0000005243531
Cebpd / Q00322 / CCAAT/enhancer-binding protein delta / P49716*ENSMUSG0000007163727
Cebpg / P53568 / CCAAT/enhancer-binding protein gamma / P53567*ENSMUSG0000005621617


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR016468  CCAAT/enhancer-binding protein, chordates


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001892 embryonic placenta development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IDA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032753 positive regulation of interleukin-4 production IDA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IDA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0045408 regulation of interleukin-6 biosynthetic process IDA
 biological_processGO:0045444 fat cell differentiation IGI
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045670 regulation of osteoclast differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050873 brown fat cell differentiation IMP
 biological_processGO:0060644 mammary gland epithelial cell differentiation IMP
 biological_processGO:0060850 regulation of transcription involved in cell fate commitment IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0072574 hepatocyte proliferation IEA
 biological_processGO:0097421 liver regeneration IMP
 biological_processGO:1901329 regulation of odontoblast differentiation ISS
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
 cellular_componentGO:0000779 condensed chromosome, centromeric region IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0036488 CHOP-C/EBP complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0035035 histone acetyltransferase binding IPI
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Senescence-Associated Secretory Phenotype (SASP)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0000647 abnormal sebaceous gland morphology "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001198 tight skin "skin has a taut, stretched appearance" [J:65038]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001236 abnormal spinous layer morphology "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0001241 absent cornified layer "missing the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Scn8aClth/Scn8aClth
Genetic Background: involves: BALB/c

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0001345 meibomian gland atrophy "wasting of the sebaceous glands embedded in the tarsal plate of each eyelid resulting in reduced size" [J:65146]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Scn8aClth/Scn8aClth
Genetic Background: involves: BALB/c

 MP:0001553 abnormal circulating free fatty acids level "anomalous blood concentrations of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Leprdb/Leprdb,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn8aClth/Scn8aClth
Genetic Background: involves: BALB/c

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amottm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Amottm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0002053 decreased incidence of induced tumors "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Leprdb/Leprdb,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002343 abnormal lymph node cortex "anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002346 abnormal lymph node secondary follicle "anomaly in the immunologically active area of the lymph node cortex " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002347 abnormal lymph node T cell domain "anomaly in the area of the lymph node in which T lymphocytes reside" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002348 abnormal lymph node medulla "anomaly in the area of the lymph node through which lymph leaves the node; it contains macrophages and antibody-secreting plasma cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002377 abnormal mucosa-associated lymphoid tissue morphology "anomalous structure or development of the regional immune system associated with the mucosa" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amottm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cebpbtm1Aki/Cebpbtm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cebpbtm1Aki/Cebpbtm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002715 reduced glycogen catabolism rate "decreased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002717 abnormal preputial gland morphology "anomalous structure of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Ins2Akita/Ins2Akita,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

 MP:0002742 enlarged submandibular lymph nodes "increased size of the submandibular lymph nodes" [J:69405, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0002992 abnormal sebaceous lipid secretion "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Ins2Akita/Ins2Akita,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

 MP:0003199 muscle calcification "pathologic deposition of calcium salts in muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003356 impaired lutenization "atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:57854, J:43075]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003357 impaired granulosa cell differentiation "atypical differentiation of the layer of small cells that forms the wall of an ovarian follicle" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43075]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Cebpbtm1Pfj/Cebpb+
Genetic Background: B6.Cg-Cebpbtm1Pfj

 MP:0004469 abnormal zygomatic arch morphology "any structural anomaly of the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpbtm1Pfj/Cebpb+
Genetic Background: B6.Cg-Cebpbtm1Pfj

Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj,Tg(Hba-x-v-Ha-ras)TG.ACLed/0
Genetic Background: involves: C57BL/6

Allelic Composition: Cebpbtm1Es/Cebpbtm1Es,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129S1 * C57BL/6J * DBA/2J

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0004817 abnormal skeletal muscle mass "anomaly in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Cebpbtm2.1Acle/Cebpbtm2.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm2.1Acle/Cebpbtm2.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0005252 abnormal meibomian gland morphology "structural anomaly of the sebaceous glands embedded in the tarsal plate of each eyelid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scn8aClth/Scn8aClth
Genetic Background: involves: BALB/c

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cebpbtm1Aki/Cebpbtm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpbtm1.1Acle/Cebpb+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

Allelic Composition: Cebpbtm2.1Acle/Cebpbtm2.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Ins2Akita/Ins2Akita,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005639 hemosiderosis "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008472 abnormal spleen secondary B follicle morphology "any strucutral anomaly of the nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp" [PMID:17495967]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cebpbtm2.1Acle/Cebpbtm2.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008618 decreased circulating interleukin-12 level "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Aki/Cebpbtm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009112 abnormal pancreatic beta cell mass "anomaly in the total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Ins2Akita/Ins2Akita,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Leprdb/Leprdb,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0009134 abnormal brown fat lipid droplet number "anomaly in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009307 decreased uterine fat pad weight 
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm2.1Acle/Cebpbtm2.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009488 pancreatic islet cell apoptosis "change in the timing or the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Ins2Akita/Ins2Akita,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Leprdb/Leprdb,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

Allelic Composition: Cebpbtm1Vpo/Cebpb+
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0009560 absent epidermis stratum granulosum "absence of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009580 increased keratinocyte apoptosis "increase in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpbtm1Es/Cebpbtm1Es,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129S1 * C57BL/6J * DBA/2J

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0009623 enlarged inguinal lymph nodes "increased size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009631 enlarged axillary lymph nodes "increased size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010172 abnormal mammary gland epithelium physiology "any functional anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0010682 abnormal hair follicle infundibulum morphology "any structural anomaly of the most proximal part of the hair follicle relative to the epidermis, extending from the sebaceous duct to the epidermal surface" [PMID:19211055]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0010688 hair follicle outer rooth sheath hyperplasia "overdevelopment or increased size, usually due to a increased number of cells, outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Cebpbtm2.1Acle/Cebpbtm2.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011224 abnormal lymph node medullary cord morphology "any structural anomaly of the dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node" [ISBN:0-683-40008-8]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011579 decreased lipoprotein lipase activity "reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
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Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
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Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0011710 increased osteoblast differentiation 
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Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0013375 abnormal sebocyte morphology "any structural anomaly of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation (holocrine secretion); these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection" [MGI:Anna, PMID:19944183]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0013376 abnormal sebocyte differentiation "abnormal formation or arrest of differentiation of the sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation; these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection; sebocyte differentiation is defined by increasing accumulation of lipid droplets, the major component of sebum" [MGI:Anna, PMID:19944183]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Cebpbtm1.1Acle/Cebpbtm1.1Acle
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000056501 Cebpb / P28033 / CCAAT/enhancer-binding protein beta / P17676*  / reaction / complex






 

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