ENSMUSG00000052435


Mus musculus

Features
Gene ID: ENSMUSG00000052435
  
Biological name :Cebpe
  
Synonyms : CCAAT/enhancer-binding protein epsilon / Cebpe / Q6PZD9
  
Possible biological names infered from orthology : Q15744
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 54710360
Gene end: 54712174
  
Corresponding Affymetrix probe sets: 10419850 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000068927
NCBI entrez gene - 110794     See in Manteia.
MGI - MGI:103572
RefSeq - NM_207131
RefSeq Peptide - NP_997014
swissprot - Q6PZD9
Ensembl - ENSMUSG00000052435
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CEBPEENSG00000092067Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cebpa / P53566 / CCAAT/enhancer-binding protein alpha / P49715*ENSMUSG0000003495739
Cebpb / P28033 / CCAAT/enhancer-binding protein beta / P17676*ENSMUSG0000005650132
Cebpd / Q00322 / CCAAT/enhancer-binding protein delta / P49716*ENSMUSG0000007163731
Cebpg / P53568 / CCAAT/enhancer-binding protein gamma / P53567*ENSMUSG0000005621616


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR016468  CCAAT/enhancer-binding protein, chordates


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006909 phagocytosis IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0030099 myeloid cell differentiation IEA
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0030851 granulocyte differentiation IEA
 biological_processGO:0042089 cytokine biosynthetic process IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0001867 rhinitis "inflammation of the mucous membrane of the nose" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0002415 abnormal neutrophil morphology/development "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0002443 abnormal eosinophil morphology/development "anomalous structure, differentiation or number of the granular leukocytes having a two-lobed nucleus and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0005190 osteomyelitis "bone inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cebpetm1Kgx/Cebpetm1Kgx
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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