ENSMUSG00000071637


Mus musculus

Features
Gene ID: ENSMUSG00000071637
  
Biological name :Cebpd
  
Synonyms : CCAAT/enhancer-binding protein delta / Cebpd / Q00322
  
Possible biological names infered from orthology : P49716
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A2
Gene start: 15887286
Gene end: 15891031
  
Corresponding Affymetrix probe sets: 10433885 (MoGene1.0st)   1423233_at (Mouse Genome 430 2.0 Array)   1456605_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148145
NCBI entrez gene - 12609     See in Manteia.
MGI - MGI:103573
RefSeq - NM_007679
RefSeq Peptide - NP_031705
swissprot - B9EIA9
swissprot - Q00322
Ensembl - ENSMUSG00000071637
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cebpdENSDARG00000087303Danio rerio
 CEBPDENSGALG00000040180Gallus gallus
 CEBPDENSG00000221869Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cebpe / Q6PZD9 / CCAAT/enhancer-binding protein epsilon / Q15744*ENSMUSG0000005243533
Cebpb / P28033 / CCAAT/enhancer-binding protein beta / P17676*ENSMUSG0000005650130
Cebpa / P53566 / CCAAT/enhancer-binding protein alpha / P49715*ENSMUSG0000003495730
Cebpg / P53568 / CCAAT/enhancer-binding protein gamma / P53567*ENSMUSG0000005621615


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR016468  CCAAT/enhancer-binding protein, chordates


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045444 fat cell differentiation IGI
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048839 inner ear development IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish
Genetic Background: involves: 129P2/OlaHsd

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008822 decreased blood uric acid level "reduced concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
Show

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0009134 abnormal brown fat lipid droplet number "anomaly in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Cebpdtm1Pfj/Cebpd+
Genetic Background: involves: 129S1/Sv

 MP:0009810 increased urine uric acid level "greater concentration in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Cebpdtm1Pfj/Cebpd+
Genetic Background: involves: 129S1/Sv

 MP:0010173 increased mammary gland epithelium proliferation "increase in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
Show

Allelic Composition: Cebpbtm1Kish/Cebpbtm1Kish,Cebpdtm1Aki/Cebpdtm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0013404 decreased circulating lactate level "reduced amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Cebpdtm1Pfj/Cebpd+
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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