ENSMUSG00000034957


Mus musculus

Features
Gene ID: ENSMUSG00000034957
  
Biological name :Cebpa
  
Synonyms : CCAAT/enhancer-binding protein alpha / Cebpa / P53566
  
Possible biological names infered from orthology : P49715
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B2
Gene start: 35119293
Gene end: 35121928
  
Corresponding Affymetrix probe sets: 10552140 (MoGene1.0st)   1418982_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096129
Ensembl peptide - ENSMUSP00000145942
NCBI entrez gene - 12606     See in Manteia.
MGI - MGI:99480
RefSeq - NM_001287523
RefSeq - NM_001287514
RefSeq - NM_001287515
RefSeq - NM_001287521
RefSeq - NM_007678
RefSeq Peptide - NP_001274450
RefSeq Peptide - NP_001274443
RefSeq Peptide - NP_001274444
RefSeq Peptide - NP_001274452
RefSeq Peptide - NP_031704
swissprot - P53566
swissprot - A0A0U1RPE0
Ensembl - ENSMUSG00000034957
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cebpaENSDARG00000036074Danio rerio
 CEBPAENSGALG00000026525Gallus gallus
 CEBPAENSG00000245848Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cebpb / P28033 / CCAAT/enhancer-binding protein beta / P17676*ENSMUSG0000005650130
Cebpe / Q6PZD9 / CCAAT/enhancer-binding protein epsilon / Q15744*ENSMUSG0000005243530
Cebpd / Q00322 / CCAAT/enhancer-binding protein delta / P49716*ENSMUSG0000007163723
Cebpg / P53568 / CCAAT/enhancer-binding protein gamma / P53567*ENSMUSG0000005621612


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR016468  CCAAT/enhancer-binding protein, chordates


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000050 urea cycle IDA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001892 embryonic placenta development IGI
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006360 transcription by RNA polymerase I ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway NAS
 biological_processGO:0030099 myeloid cell differentiation IDA
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030851 granulocyte differentiation IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III IEA
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048839 inner ear development IDA
 biological_processGO:0050872 white fat cell differentiation IMP
 biological_processGO:0050873 brown fat cell differentiation IDA
 biological_processGO:0055088 lipid homeostasis IMP
 biological_processGO:0071285 cellular response to lithium ion IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:2000144 positive regulation of DNA-templated transcription, initiation ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001013 RNA polymerase I regulatory region DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Cebpatm8.1Nerl/Cebpa+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Cebpatm2Btp/Cebpatm2Btp
Genetic Background: B6.129P2-Cebpatm2Btp

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0000239 deficiency of myeloid colony forming progenitor cells "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Gjd/Cebpatm1Gjd
Genetic Background: B6.129S7-Cebpatm1Gjd

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Cebpatm2Nerl/Cebpatm2Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cebpatm4Nerl/Cebpatm4Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm5Nerl/Cebpatm5Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm5Nerl/Cebpatm5Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cebpatm6Nerl/Cebpatm6Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000647 abnormal sebaceous gland morphology "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Cebpatm2Btp/Cebpatm2Btp
Genetic Background: B6.129P2-Cebpatm2Btp

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001198 tight skin "skin has a taut, stretched appearance" [J:65038]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001236 abnormal spinous layer morphology "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0001241 absent cornified layer "missing the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0001345 meibomian gland atrophy "wasting of the sebaceous glands embedded in the tarsal plate of each eyelid resulting in reduced size" [J:65146]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm8.1Nerl/Cebpa+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

Allelic Composition: Cebpatm1Timc/Cebpatm1Timc
Genetic Background: Not Specified

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm6Nerl/Cebpatm6Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Cebpatm2Btp/Cebpatm2Btp
Genetic Background: B6.129P2-Cebpatm2Btp

 MP:0001603 failure of myelopoiesis "missing the process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:60896]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Cebpatm1Gjd/Cebpatm1Gjd
Genetic Background: B6.129S7-Cebpatm1Gjd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1(Cebpb)Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cebpatm2Nerl/Cebpatm2Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cebpatm4Nerl/Cebpatm4Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001934 increased litter size "greater numbers of live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Cebpatm2Nerl/Cebpatm2Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cebpatm4Nerl/Cebpatm4Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Cebpatm2Btp/Cebpatm2Btp
Genetic Background: B6.129P2-Cebpatm2Btp

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cebpatm1Nerl/Cebpatm1Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0002274 abnormal type I pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli through which gas exchange occurs; these are thin cells with a large surface area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm2Btp/Cebpatm2Btp
Genetic Background: B6.129P2-Cebpatm2Btp

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Cebpatm2Nerl/Cebpatm2Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cebpatm4Nerl/Cebpatm4Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Timc/Cebpatm1Timc
Genetic Background: Not Specified

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0002717 abnormal preputial gland morphology "anomalous structure of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Timc/Cebpatm1Timc
Genetic Background: Not Specified

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1(Cebpb)Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1(Cebpb)Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002992 abnormal sebaceous lipid secretion "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm2Btp/Cebpatm2Btp
Genetic Background: B6.129P2-Cebpatm2Btp

 MP:0003326 liver failure "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Timc/Cebpatm1Timc
Genetic Background: Not Specified

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Timc/Cebpatm1Timc
Genetic Background: Not Specified

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm2Btp/Cebpatm2Btp
Genetic Background: B6.129P2-Cebpatm2Btp

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005252 abnormal meibomian gland morphology "structural anomaly of the sebaceous glands embedded in the tarsal plate of each eyelid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpatm6Nerl/Cebpatm6Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Cebpatm2Nerl/Cebpatm2Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cebpatm4Nerl/Cebpatm4Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005336 abnormal inguinal fat pad "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Cebpatm1Timc/Cebpatm1Timc
Genetic Background: Not Specified

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm6Nerl/Cebpatm6Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cebpatm6Nerl/Cebpatm6Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Timc/Cebpatm1Timc
Genetic Background: Not Specified

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1(Cebpb)Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Cebpatm8.1Nerl/Cebpa+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008991 abnormal bile canaliculus morphology "any structural anomaly of the intercellular channels that take up bile from hepatocytes and transport it to the bile ducts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1(Cebpb)Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm5Nerl/Cebpatm5Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009560 absent epidermis stratum granulosum "absence of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Cebpatm1Gonz/Cebpatm9Nerl,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0010682 abnormal hair follicle infundibulum morphology "any structural anomaly of the most proximal part of the hair follicle relative to the epidermis, extending from the sebaceous duct to the epidermal surface" [PMID:19211055]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0010688 hair follicle outer rooth sheath hyperplasia "overdevelopment or increased size, usually due to a increased number of cells, outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010812 absent type II pneumocytes "absence of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0010814 absent alveolar lamellar bodies "absence of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0010817 absent type I pneumocytes "absence of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010903 abnormal pulmonary alveolus wall morphology 
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cebpatm1Kgx/Cebpatm1Kgx
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cebpatm1Dgt/Cebpatm1Dgt,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1(Cebpb)Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0013375 abnormal sebocyte morphology "any structural anomaly of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation (holocrine secretion); these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection" [MGI:Anna, PMID:19944183]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0013376 abnormal sebocyte differentiation "abnormal formation or arrest of differentiation of the sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation; these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection; sebocyte differentiation is defined by increasing accumulation of lipid droplets, the major component of sebum" [MGI:Anna, PMID:19944183]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Es/Cebpbtm1Es,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0013723 increased circulating tyrosine level "the amount of the amino acid histidine in the blood is more than expected" [MGI:csmith]
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Allelic Composition: Dmc1Mei11/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Cebpatm6Nerl/Cebpatm6Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Cebpatm6Nerl/Cebpatm6Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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