ENSG00000173039


Homo sapiens

Features
Gene ID: ENSG00000173039
  
Biological name :RELA
  
Synonyms : Q04206 / RELA / RELA proto-oncogene, NF-kB subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.1
Gene start: 65653596
Gene end: 65663094
  
Corresponding Affymetrix probe sets: 201783_s_at (Human Genome U133 Plus 2.0 Array)   209878_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434008
Ensembl peptide - ENSP00000431153
Ensembl peptide - ENSP00000431304
Ensembl peptide - ENSP00000432537
Ensembl peptide - ENSP00000432922
Ensembl peptide - ENSP00000433144
Ensembl peptide - ENSP00000433526
Ensembl peptide - ENSP00000433616
Ensembl peptide - ENSP00000434098
Ensembl peptide - ENSP00000483705
Ensembl peptide - ENSP00000479572
Ensembl peptide - ENSP00000437137
Ensembl peptide - ENSP00000436545
Ensembl peptide - ENSP00000435531
Ensembl peptide - ENSP00000435290
Ensembl peptide - ENSP00000434745
Ensembl peptide - ENSP00000434372
Ensembl peptide - ENSP00000311508
Ensembl peptide - ENSP00000384273
NCBI entrez gene - 5970     See in Manteia.
OMIM - 164014
RefSeq - XM_011545206
RefSeq - NM_021975
RefSeq - NM_001243985
RefSeq - NM_001243984
RefSeq - NM_001145138
RefSeq - XM_011545207
RefSeq Peptide - NP_001230913
RefSeq Peptide - NP_001138610
RefSeq Peptide - NP_001230914
RefSeq Peptide - NP_068810
swissprot - E9PNV4
swissprot - E9PNK5
swissprot - E9PN69
swissprot - E9PMD5
swissprot - E9PM47
swissprot - H0YCB4
swissprot - E9PKV4
swissprot - E9PKH5
swissprot - E9PJZ9
swissprot - E9PJR1
swissprot - Q2TAM5
swissprot - E9PI38
swissprot - A0A087X0W8
swissprot - A0A087WVP0
swissprot - Q04206
swissprot - E9PSE4
swissprot - E9PRX2
swissprot - E9PQS6
Ensembl - ENSG00000173039
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 relaENSDARG00000098696Danio rerio
 RelaENSMUSG00000024927Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
REL / Q04864 / REL proto-oncogene, NF-kB subunitENSG0000016292440
RELB / Q01201 / RELB proto-oncogene, NF-kB subunitENSG0000010485633
NFKB1 / P19838 / nuclear factor kappa B subunit 1ENSG0000010932031
NFKB2 / Q00653 / nuclear factor kappa B subunit 2ENSG0000007715029


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR030492  Rel homology domain, conserved site
 IPR030495  Transcription factor RelA (p65)
 IPR032397  Rel homology dimerisation domain
 IPR033926  NFkappaB IPT domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006117 acetaldehyde metabolic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0006968 cellular defense response NAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0010224 response to UV-B IDA
 biological_processGO:0014040 positive regulation of Schwann cell differentiation IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis TAS
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0032495 response to muramyl dipeptide IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0033234 negative regulation of protein sumoylation IEA
 biological_processGO:0033590 response to cobalamin IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043620 regulation of DNA-templated transcription in response to stress IMP
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050727 regulation of inflammatory response ISS
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051607 defense response to virus NAS
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0070555 response to interleukin-1 IGI
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IMP
 biological_processGO:0071224 cellular response to peptidoglycan IMP
 biological_processGO:0071316 cellular response to nicotine IMP
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0071354 cellular response to interleukin-6 IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling IGI
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IMP
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:1904385 cellular response to angiotensin IMP
 biological_processGO:2000630 positive regulation of miRNA metabolic process IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 cellular_componentGO:0035525 NF-kappaB p50/p65 complex IDA
 cellular_componentGO:0071159 NF-kappaB complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0042301 phosphate ion binding IDA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0042805 actinin binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0051059 NF-kappaB binding IPI
 molecular_functionGO:0070491 repressing transcription factor binding IPI
 molecular_functionGO:0071532 ankyrin repeat binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
The NLRP3 inflammasome
Interleukin-1 signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction / complex
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / complex
 ENSG00000100906 NFKBIA / P25963 / NFKB inhibitor alpha  / complex
 ENSG00000103037 SETD6 / Q8TBK2 / SET domain containing 6  / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex
 ENSG00000104856 RELB / Q01201 / RELB proto-oncogene, NF-kB subunit  / reaction / complex
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / complex / reaction
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / complex / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / complex
 ENSG00000104825 NFKBIB / Q15653 / NFKB inhibitor beta  / complex
 ENSG00000146232 NFKBIE / O00221 / NFKB inhibitor epsilon  / complex
 ENSG00000172216 CEBPB / P17676 / CCAAT/enhancer binding protein beta  / complex / reaction
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / reaction
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / reaction
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / reaction
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / reaction
 ENSG00000100784 O75582 / RPS6KA5 / ribosomal protein S6 kinase A5  / reaction






 

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