ENSG00000146232


Homo sapiens

Features
Gene ID: ENSG00000146232
  
Biological name :NFKBIE
  
Synonyms : NFKBIE / NFKB inhibitor epsilon / O00221
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.1
Gene start: 44258166
Gene end: 44265788
  
Corresponding Affymetrix probe sets: 203927_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394658
Ensembl peptide - ENSP00000480216
Ensembl peptide - ENSP00000454778
Ensembl peptide - ENSP00000275015
NCBI entrez gene - 4794     See in Manteia.
OMIM - 604548
RefSeq - NM_004556
RefSeq Peptide - NP_004547
swissprot - O00221
swissprot - A0A024RD24
swissprot - Q7LC14
swissprot - H0Y4W4
swissprot - H3BNC2
Ensembl - ENSG00000146232
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfkbieENSDARG00000068367Danio rerio
 NFKBIEENSGALG00000044525Gallus gallus
 NfkbieENSMUSG00000023947Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BCL3 / P20749 / B cell CLL/lymphoma 3ENSG0000006939925
NFKBIZ / Q9BYH8 / NFKB inhibitor zetaENSG0000014480222
NFKBIB / Q15653 / NFKB inhibitor betaENSG0000010482522
NFKBIA / P25963 / NFKB inhibitor alphaENSG0000010090621
NFKBID / Q8NI38 / NFKB inhibitor deltaENSG0000016760416


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042942 D-serine transport IEA
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor TAS
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / reaction / complex
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / complex
 ENSG00000162924 REL / Q04864 / REL proto-oncogene, NF-kB subunit  / complex
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / reaction / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / reaction






 

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