ENSG00000104825


Homo sapiens

Features
Gene ID: ENSG00000104825
  
Biological name :NFKBIB
  
Synonyms : NFKBIB / NFKB inhibitor beta / Q15653
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 38899700
Gene end: 38908893
  
Corresponding Affymetrix probe sets: 214062_x_at (Human Genome U133 Plus 2.0 Array)   214448_x_at (Human Genome U133 Plus 2.0 Array)   228388_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461617
Ensembl peptide - ENSP00000458685
Ensembl peptide - ENSP00000459728
Ensembl peptide - ENSP00000312988
Ensembl peptide - ENSP00000375929
Ensembl peptide - ENSP00000438598
NCBI entrez gene - 4793     See in Manteia.
OMIM - 604495
RefSeq - XM_006723227
RefSeq - NM_001243116
RefSeq - NM_002503
RefSeq - XM_006723226
RefSeq Peptide - NP_002494
RefSeq Peptide - NP_001230045
swissprot - I3L4X3
swissprot - Q15653
swissprot - H0YFH0
swissprot - I3L1A4
swissprot - G5E9C2
Ensembl - ENSG00000104825
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfkbibENSDARG00000030087Danio rerio
 NFKBIBENSGALG00000029691Gallus gallus
 NfkbibENSMUSG00000030595Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BCL3 / P20749 / B cell CLL/lymphoma 3ENSG0000006939931
NFKBIE / O00221 / NFKB inhibitor epsilonENSG0000014623230
NFKBIA / P25963 / NFKB inhibitor alphaENSG0000010090629
NFKBIZ / Q9BYH8 / NFKB inhibitor zetaENSG0000014480223
NFKBID / Q8NI38 / NFKB inhibitor deltaENSG0000016760419


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / complex / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / complex
 ENSG00000162924 REL / Q04864 / REL proto-oncogene, NF-kB subunit  / complex
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / complex
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / reaction






 

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