ENSG00000069399


Homo sapiens

Features
Gene ID: ENSG00000069399
  
Biological name :BCL3
  
Synonyms : B cell CLL/lymphoma 3 / BCL3 / P20749
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 44747705
Gene end: 44760044
  
Corresponding Affymetrix probe sets: 204907_s_at (Human Genome U133 Plus 2.0 Array)   204908_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000164227
Ensembl peptide - ENSP00000393731
NCBI entrez gene - 602     See in Manteia.
OMIM - 109560
RefSeq - XM_017027110
RefSeq - NM_005178
RefSeq - XM_011527198
RefSeq - XM_011527200
RefSeq - XM_017027109
RefSeq - XM_011527197
RefSeq Peptide - NP_005169
swissprot - P20749
swissprot - H7C0A2
Ensembl - ENSG00000069399
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl3ENSDARG00000087832Danio rerio
 Bcl3ENSMUSG00000053175Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFKBIE / O00221 / NFKB inhibitor epsilonENSG0000014623227
NFKBIZ / Q9BYH8 / NFKB inhibitor zetaENSG0000014480226
NFKBIB / Q15653 / NFKB inhibitor betaENSG0000010482524
NFKBID / Q8NI38 / NFKB inhibitor deltaENSG0000016760419
NFKBIA / P25963 / NFKB inhibitor alphaENSG0000010090618


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IMP
 biological_processGO:0002268 follicular dendritic cell differentiation IEA
 biological_processGO:0002315 marginal zone B cell differentiation IEA
 biological_processGO:0002455 humoral immune response mediated by circulating immunoglobulin IEA
 biological_processGO:0002467 germinal center formation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0010225 response to UV-C IDA
 biological_processGO:0019730 antimicrobial humoral response IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0042088 T-helper 1 type immune response IEA
 biological_processGO:0042536 negative regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:0042832 defense response to protozoan IEA
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045064 T-helper 2 cell differentiation IEA
 biological_processGO:0045082 positive regulation of interleukin-10 biosynthetic process IEA
 biological_processGO:0045415 negative regulation of interleukin-8 biosynthetic process IMP
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IMP
 biological_processGO:0048536 spleen development IEA
 biological_processGO:0051101 regulation of DNA binding IEP
 biological_processGO:0051457 maintenance of protein location in nucleus NAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0032996 Bcl3-Bcl10 complex IDA
 cellular_componentGO:0033257 Bcl3/NF-kappaB2 complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0030674 protein binding, bridging TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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