ENSMUSG00000053175


Mus musculus

Features
Gene ID: ENSMUSG00000053175
  
Biological name :Bcl3
  
Synonyms : B-cell lymphoma 3 protein homolog / Bcl3 / Q9Z2F6
  
Possible biological names infered from orthology : B cell CLL/lymphoma 3 / P20749
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19808462
Gene end: 19822770
  
Corresponding Affymetrix probe sets: 10560685 (MoGene1.0st)   1418133_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113851
Ensembl peptide - ENSMUSP00000117754
NCBI entrez gene - 12051     See in Manteia.
MGI - MGI:88140
RefSeq - NM_033601
RefSeq - XM_006539487
RefSeq Peptide - NP_291079
swissprot - F6YNH8
swissprot - Q9Z2F6
Ensembl - ENSMUSG00000053175
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl3ENSDARG00000087832Danio rerio
 BCL3ENSG00000069399Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*ENSMUSG0000002394725
Nfkbiz / Q9EST8 / NF-kappa-B inhibitor zeta / Q9BYH8* / NFKB inhibitor zeta*ENSMUSG0000003535623
Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*ENSMUSG0000003059523
Nfkbid / Q2TB02 / NF-kappa-B inhibitor delta / Q8NI38* / NFKB inhibitor delta*ENSMUSG0000003693119
Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*ENSMUSG0000002102518


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0002268 follicular dendritic cell differentiation IMP
 biological_processGO:0002315 marginal zone B cell differentiation IMP
 biological_processGO:0002455 humoral immune response mediated by circulating immunoglobulin IMP
 biological_processGO:0002467 germinal center formation IMP
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010225 response to UV-C IEA
 biological_processGO:0019730 antimicrobial humoral response IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0042088 T-helper 1 type immune response IMP
 biological_processGO:0042536 negative regulation of tumor necrosis factor biosynthetic process IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045064 T-helper 2 cell differentiation IMP
 biological_processGO:0045082 positive regulation of interleukin-10 biosynthetic process IMP
 biological_processGO:0045415 negative regulation of interleukin-8 biosynthetic process IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IEA
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0051101 regulation of DNA binding IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032996 Bcl3-Bcl10 complex IEA
 cellular_componentGO:0033257 Bcl3/NF-kappaB2 complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Fn1tm1Bwg/Fn1tm1Bwg
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bcl3m1Btlr/Bcl3m1Btlr
Genetic Background: C57BL/6J-Bcl3m1Btlr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl3m1Btlr/Bcl3m1Btlr
Genetic Background: C57BL/6J-Bcl3m1Btlr

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm1Cgn/Rag2tm1Cgn,Tg(Cr2-cre)3Cgn/?,Xrcc4tm1Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag2tm1Cgn/Rag2tm1Cgn,Tg(Cr2-cre)3Cgn/?,Xrcc4tm1Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0002392 abnormal Peyer s patch T cell area "anomalous structure or development of the Peyer s patch normally occupied by T lymphcytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Fn1tm1Bwg/Fn1tm1Bwg
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bcl3tm1Rsch/Bcl3tm1Rsch
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il10tm1Flv/Il10tm1Flv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl3tm1Rsch/Bcl3tm1Rsch
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl3m1Btlr/Bcl3m1Btlr
Genetic Background: C57BL/6J-Bcl3m1Btlr

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag2tm1Cgn/Rag2tm1Cgn,Tg(Cr2-cre)3Cgn/?,Xrcc4tm1Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl3tm1Rsch/Bcl3tm1Rsch
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Bcl3tm1Rsch/Bcl3tm1Rsch
Genetic Background: B6.Cg-Bcl3tm1Rsch

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl3m1Btlr/Bcl3m1Btlr
Genetic Background: C57BL/6J-Bcl3m1Btlr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bcl3m1Btlr/Bcl3m1Btlr
Genetic Background: C57BL/6J-Bcl3m1Btlr

Allelic Composition: Bcl3m1Btlr/Bcl3+
Genetic Background: C57BL/6J-Bcl3m1Btlr

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Bcl3m1Btlr/Bcl3m1Btlr
Genetic Background: C57BL/6J-Bcl3m1Btlr

Allelic Composition: Bcl3m1Btlr/Bcl3+
Genetic Background: C57BL/6J-Bcl3m1Btlr

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl3tm1Rsch/Bcl3tm1Rsch
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0006173 abnormal Langerhans cell morphology/development "anomaly in the formation or structure of phagocytic dendritic cells principally found in the epidemis and mucosal epithelium" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95147]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl3m1Btlr/Bcl3m1Btlr
Genetic Background: C57BL/6J-Bcl3m1Btlr

Allelic Composition: Bcl3m1Btlr/Bcl3+
Genetic Background: C57BL/6J-Bcl3m1Btlr

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008125 abnormal dendritic cell number "anomaly in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0008170 decreased B-1b cell number "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Bcl3m1Btlr/Bcl3m1Btlr
Genetic Background: C57BL/6J-Bcl3m1Btlr

Allelic Composition: Bcl3m1Btlr/Bcl3+
Genetic Background: C57BL/6J-Bcl3m1Btlr

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008196 abnormal follicular dendritic cell morphology "any structural anomaly of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0008240 abnormal spleen marginal zone macrophage morphology "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008241 abnormal metallophilic macrophage morphology "any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus" [PMID:16322748]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Fn1tm1Bwg/Fn1tm1Bwg
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl3tm1Sbn/Bcl3tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010841 increased central memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
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Allelic Composition: Bcl3m1Btlr/Bcl3m1Btlr
Genetic Background: C57BL/6J-Bcl3m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr