Manteia

ENSMUSG00000035356

Mus musculus

Features

Gene ID:	ENSMUSG00000035356

Biological name :	Nfkbiz

Synonyms :	NF-kappa-B inhibitor zeta / Nfkbiz / Q9EST8

Possible biological names infered from orthology :	NFKB inhibitor zeta / Q9BYH8

Species:	Mus musculus

Chr. number:	16
Strand:	-1
Band:	C1.1
Gene start:	55811375
Gene end:	55838899

Corresponding Affymetrix probe sets:	10439936 (MoGene1.0st) 1417483_at (Mouse Genome 430 2.0 Array) 1448728_a_at (Mouse Genome 430 2.0 Array) 1457404_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000041173 Ensembl peptide - ENSMUSP00000093726 Ensembl peptide - ENSMUSP00000110101 Ensembl peptide - ENSMUSP00000110102 NCBI entrez gene - 80859 See in Manteia. MGI - MGI:1931595 RefSeq - NM_001159394 RefSeq - NM_001159395 RefSeq - NM_030612 RefSeq Peptide - NP_001152866 RefSeq Peptide - NP_001152867 RefSeq Peptide - NP_085115 swissprot - Q9EST8 Ensembl - ENSMUSG00000035356

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nfkbiz	ENSDARG00000102097	Danio rerio
NFKBIZ	ENSGALG00000015346	Gallus gallus
NFKBIZ	ENSG00000144802	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Nfkbid / Q2TB02 / NF-kappa-B inhibitor delta / Q8NI38* / NFKB inhibitor delta*	ENSMUSG00000036931	18
Bcl3 / Q9Z2F6 / B-cell lymphoma 3 protein homolog / P20749* / B cell CLL/lymphoma 3*	ENSMUSG00000053175	14
Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*	ENSMUSG00000023947	13
Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*	ENSMUSG00000030595	11
Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*	ENSMUSG00000021025	10

Protein motifs (from Interpro)

Interpro ID	Name
IPR002110	Ankyrin repeat
IPR020683	Ankyrin repeat-containing domain
IPR036770	Ankyrin repeat-containing domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IBA
biological_process	GO:0006954	inflammatory response	IDA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0016607	nuclear speck	ISO
cellular_component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO
molecular_function	GO:0003712	transcription coregulator activity	IBA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Plat^tm1Mlg/Plat^tm1Mlg Genetic Background: B6.Cg-Plat^tm1Mlg Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0001190	reddish skin	"skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]	Show Allelic Composition: Dhcr7^tm1Gst/Dhcr7^tm1Gst,Tg(APOE-DHCR7)2Hoyu/0 Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6J * FVB/N
MP:0001191	abnormal skin condition	"anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plat^tm1Mlg/Plat^tm1Mlg Genetic Background: B6.Cg-Plat^tm1Mlg
MP:0001192	scaly skin	"skin covered with shedding scales or flakes" [J:65146]	Show Allelic Composition: Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo Genetic Background: involves: 129S7/SvEvBrd
MP:0001194	dermatitis	"inflammation of the skin" [J:65146]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Stat6^tm1Aki/Stat6^tm1Aki Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki Allelic Composition: Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta,Tg(CAG-cre)13Miya/? Genetic Background: involves: C57BL/6 Allelic Composition: Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta,Tg(KRT5-cre)1Tak/? Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Tnf^tm1Sek/Tnf^tm1Sek Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
MP:0001200	thick skin	"greater depth of skin " [J:47225]	Show Allelic Composition: Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo Genetic Background: involves: 129S7/SvEvBrd
MP:0001209	spontaneous skin ulceration	"unpredictable appearance of skin lesions, usually with inflammation" [J:65302]	Show Allelic Composition: Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo Genetic Background: involves: 129S7/SvEvBrd
MP:0001212	skin lesions	"focal patches of inflammation on the skin" [J:30162]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0001216	abnormal epidermal layer morphology	"anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dhcr7^tm1Gst/Dhcr7^tm1Gst,Tg(APOE-DHCR7)2Hoyu/0 Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6J * FVB/N
MP:0001222	epidermal hyperplasia	"increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Stat6^tm1Aki/Stat6^tm1Aki Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Stat6^tm1Aki/Stat6^tm1Aki Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki
MP:0001412	excessive scratching	"compulsive scraping of the skin, usually with the nails" [J:61340]	Show Allelic Composition: Plat^tm1Mlg/Plat^tm1Mlg Genetic Background: B6.Cg-Plat^tm1Mlg
MP:0001786	skin edema	"accumulation of an excessive amount of fluid in the skin" [J:65039]	Show Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Stat6^tm1Aki/Stat6^tm1Aki Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0001851	eye inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Stat6^tm1Aki/Stat6^tm1Aki Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki
MP:0001852	conjunctivitis	"inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Tnf^tm1Sek/Tnf^tm1Sek Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
MP:0001862	interstitial pneumonia	"disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0001874	acanthosis	"diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz⁺,Stat6^tm1Aki/Stat6^tm1Aki Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki
MP:0002060	abnormal skin morphology	"malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Plat^tm1Mlg/Plat^tm1Mlg Genetic Background: B6.Cg-Plat^tm1Mlg
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dhcr7^tm1Gst/Dhcr7^tm1Gst,Tg(APOE-DHCR7)2Hoyu/0 Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6J * FVB/N
MP:0002433	abnormal T helper 1 morphology/development	"anomalous structure, formation, or numbers of the subset of helper T cells that enhance cell-mediated immune responses. These cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0002442	abnormal leukocyte physiology	"abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0002461	increased circulating immunoglobulin concentration	"greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0002497	increased IgE	"greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki
MP:0002619	abnormal lymphocyte morphology/development	"anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0003427	parakeratosis	"abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo Genetic Background: involves: 129S7/SvEvBrd
MP:0004481	abnormal conjunctival epithelium	"any structural anomaly in the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Stat6^tm1Aki/Stat6^tm1Aki Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki
MP:0004947	skin inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Stat6^tm1Aki/Stat6^tm1Aki Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz⁺,Stat6^tm1Aki/Stat6^tm1Aki Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki
MP:0005251	blepharitis	"inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Stat6^tm1Aki/Stat6^tm1Aki Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki
MP:0006167	eyelid edema	"an abnormal accumulation of fluid in the eyelid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta,Tg(CAG-cre)13Miya/? Genetic Background: involves: C57BL/6 Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki,Tnf^tm1Sek/Tnf^tm1Sek Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
MP:0008556	abnormal tumor necrosis factor secretion	"anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0008664	decreased interleukin-12 secretion	"reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0008706	decreased interleukin-6 secretion	"reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0008828	abnormal lymph node cell ratio	"deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0008880	lacrimal gland inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki
MP:0012164	abnormal conjunctiva goblet cell morphology	"any structural anomaly of a goblet cell that is part of the epithelium of the conjunctiva, and is the source of tear mucins which are secreted from it" [MGI:csmith]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0013452	increased lacrimal gland apoptosis	" increase in the number of cells of the lacrimal gland undergoing programmed cell death" [MGI:Anna]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta,Tg(KRT5-cre)1Tak/? Genetic Background: involves: C3H * C57BL/6
MP:0013459	perioral dermatitis	"an inflammatory skin condition characterized by multiple small papules, pustules and vesicles localized to the perioral skin (around the mouth), perinasal or nasolabial folds (around the nostrils), or periocular area (around the eyes)" [http://en.wikipedia.org/wiki/Perioral_dermatitis]	Show Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki
MP:0013460	periocular dermatitis	"inflammation of the skin on the eyelids and around the eyes; a variant of perioral dermatitis" [MGI:Anna]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0013464	decreased conjunctiva goblet cell number	"fewer than normal numbers of the mucin-secreting cells found on the conjunctival epithelium; goblet cell loss has been reported in several inflammatory diseases of the ocular surface, including Stevens-Johnson syndrome, ocular mucous membrane pemphigoid, alkali burn, neutrophilic keratitis, graft-versus-host-disease, and Sjogrens s syndrome" [MGI:Anna]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1) Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Genetic Background: C.129P2-Nfkbiz^tm1Aki
MP:0013478	corneal limbitis	"inflammation of the corneal limbus" [MGI:Anna]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
MP:0020220	decreased tear production	"decreased production of the amount of fluid produced in the eye" [GOC:NV]	Show Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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