ENSMUSG00000023947


Mus musculus

Features
Gene ID: ENSMUSG00000023947
  
Biological name :Nfkbie
  
Synonyms : NF-kappa-B inhibitor epsilon / Nfkbie / O54910
  
Possible biological names infered from orthology : NFKB inhibitor epsilon / O00221
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B3
Gene start: 45555716
Gene end: 45563169
  
Corresponding Affymetrix probe sets: 10445412 (MoGene1.0st)   1431843_a_at (Mouse Genome 430 2.0 Array)   1458299_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024742
NCBI entrez gene - 18037     See in Manteia.
MGI - MGI:1194908
RefSeq - NM_008690
RefSeq - NM_001304956
RefSeq Peptide - NP_001291885
RefSeq Peptide - NP_032716
swissprot - O54910
Ensembl - ENSMUSG00000023947
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfkbieENSDARG00000068367Danio rerio
 NFKBIEENSGALG00000044525Gallus gallus
 NFKBIEENSG00000146232Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcl3 / Q9Z2F6 / B-cell lymphoma 3 protein homolog / P20749* / B cell CLL/lymphoma 3*ENSMUSG0000005317531
Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*ENSMUSG0000003059529
Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*ENSMUSG0000002102528
Nfkbiz / Q9EST8 / NF-kappa-B inhibitor zeta / Q9BYH8* / NFKB inhibitor zeta*ENSMUSG0000003535626
Nfkbid / Q2TB02 / NF-kappa-B inhibitor delta / Q8NI38* / NFKB inhibitor delta*ENSMUSG0000003693123


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042942 D-serine transport IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated RCA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fertm1Pag/Fertm1Pag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fertm1Pag/Fertm1Pag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fertm1Pag/Fertm1Pag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex
 ENSMUSG00000020271 Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / reaction / complex
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / complex
 ENSMUSG00000020275 Rel / reticuloendotheliosis oncogene / Q04864* / REL proto-oncogene, NF-kB subunit*  / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr