ENSMUSG00000036931


Mus musculus

Features
Gene ID: ENSMUSG00000036931
  
Biological name :Nfkbid
  
Synonyms : NF-kappa-B inhibitor delta / Nfkbid / Q2TB02
  
Possible biological names infered from orthology : NFKB inhibitor delta / Q8NI38
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B1
Gene start: 30421732
Gene end: 30428746
  
Corresponding Affymetrix probe sets: 10551891 (MoGene1.0st)   1436074_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042317
Ensembl peptide - ENSMUSP00000103810
Ensembl peptide - ENSMUSP00000103811
NCBI entrez gene - 243910     See in Manteia.
MGI - MGI:3041243
RefSeq - XM_011250574
RefSeq - NM_172142
RefSeq - XM_006539952
RefSeq - XM_006539953
RefSeq - XM_011250573
RefSeq - XM_006539951
RefSeq Peptide - NP_742154
swissprot - Q2TB02
swissprot - A0A217FL61
Ensembl - ENSMUSG00000036931
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000028496Gallus gallus
 NFKBIDENSG00000167604Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfkbiz / Q9EST8 / NF-kappa-B inhibitor zeta / Q9BYH8* / NFKB inhibitor zeta*ENSMUSG0000003535640
Bcl3 / Q9Z2F6 / B-cell lymphoma 3 protein homolog / P20749* / B cell CLL/lymphoma 3*ENSMUSG0000005317527
Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*ENSMUSG0000002394725
Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*ENSMUSG0000002102520
Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*ENSMUSG0000003059520


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0033085 negative regulation of T cell differentiation in thymus IDA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0070245 positive regulation of thymocyte apoptotic process IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003712 transcription coregulator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051059 NF-kappaB binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zeb1m1Btlr/Zeb1m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zeb1m1Btlr/Zeb1m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myoz1tm1a(EUCOMM)Hmgu/Myoz1tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myoz1tm1a(EUCOMM)Hmgu/Myoz1tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: H2b/H2b,Nfkbidtm1Clay/Nfkbidtm1Clay,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/?
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zeb1m1Btlr/Zeb1m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myoz1tm1a(EUCOMM)Hmgu/Myoz1tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zeb1m1Btlr/Zeb1m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myoz1tm1a(EUCOMM)Hmgu/Myoz1tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zeb1m1Btlr/Zeb1m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: H2b/H2b,Nfkbidtm1Clay/Nfkbidtm1Clay,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/?
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Zeb1m1Btlr/Zeb1m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Zeb1m1Btlr/Zeb1m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zeb1m1Btlr/Zeb1m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zeb1m1Btlr/Zeb1m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: H2b/H2b,Nfkbidtm1Clay/Nfkbidtm1Clay,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/?
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zeb1m1Btlr/Zeb1m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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