ENSG00000103037


Homo sapiens

Features
Gene ID: ENSG00000103037
  
Biological name :SETD6
  
Synonyms : Q8TBK2 / SETD6 / SET domain containing 6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q21
Gene start: 58515479
Gene end: 58521181
  
Corresponding Affymetrix probe sets: 1554555_a_at (Human Genome U133 Plus 2.0 Array)   219751_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398033
Ensembl peptide - ENSP00000377809
Ensembl peptide - ENSP00000412858
Ensembl peptide - ENSP00000396437
Ensembl peptide - ENSP00000219315
Ensembl peptide - ENSP00000310082
NCBI entrez gene - 79918     See in Manteia.
OMIM - 616424
RefSeq - XM_011523336
RefSeq - NM_001160305
RefSeq - NM_024860
RefSeq Peptide - NP_001153777
RefSeq Peptide - NP_079136
swissprot - E9PC53
swissprot - J3QT10
swissprot - H7C3N0
swissprot - C9JCR1
swissprot - Q8TBK2
Ensembl - ENSG00000103037
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setd6ENSDARG00000043986Danio rerio
 SETD6ENSGALG00000002247Gallus gallus
 Setd6ENSMUSG00000031671Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR011383  N-lysine methyltransferase SETD6
 IPR015353  Rubisco LSMT, substrate-binding domain
 IPR036464  Rubisco LSMT, substrate-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018026 peptidyl-lysine monomethylation IDA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IDA
 biological_processGO:0048863 stem cell differentiation IEA
 biological_processGO:0050727 regulation of inflammatory response IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051059 NF-kappaB binding IPI


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / reaction
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / reaction






 

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