Manteia

ENSMUSG00000031671

Mus musculus

Features

Gene ID:	ENSMUSG00000031671

Biological name :	Setd6

Synonyms :	N-lysine methyltransferase SETD6 / Q9CWY3 / Setd6

Possible biological names infered from orthology :	Q8TBK2 / SET domain containing 6

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	D1
Gene start:	95715881
Gene end:	95719010

Corresponding Affymetrix probe sets:	10574404 (MoGene1.0st) 1428797_at (Mouse Genome 430 2.0 Array) 1428798_s_at (Mouse Genome 430 2.0 Array) 1457158_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000034096 Ensembl peptide - ENSMUSP00000148785 Ensembl peptide - ENSMUSP00000148466 NCBI entrez gene - 66083 See in Manteia. MGI - MGI:1913333 RefSeq - NM_001035123 RefSeq Peptide - NP_001030295 swissprot - A0A1D5RMH9 swissprot - A0A1D5RLQ7 swissprot - Q9CWY3 Ensembl - ENSMUSG00000031671

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
setd6	ENSDARG00000043986	Danio rerio
SETD6	ENSGALG00000002247	Gallus gallus
SETD6	ENSG00000103037	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001214	SET domain
IPR011383	N-lysine methyltransferase SETD6
IPR015353	Rubisco LSMT, substrate-binding domain
IPR036464	Rubisco LSMT, substrate-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0018026	peptidyl-lysine monomethylation	IBA
biological_process	GO:0019827	stem cell population maintenance	IDA
biological_process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IEA
biological_process	GO:0032259	methylation	IEA
biological_process	GO:0034968	histone lysine methylation	IEA
biological_process	GO:0048863	stem cell differentiation	IDA
biological_process	GO:0050727	regulation of inflammatory response	IEA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008168	methyltransferase activity	IEA
molecular_function	GO:0016279	protein-lysine N-methyltransferase activity	IBA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0051059	NF-kappaB binding	IEA

Pathways (from Reactome)

Pathway description

PKMTs methylate histone lysines

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005627	increased circulating potassium level	"greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0011275	abnormal behavioral response to light	"unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0012121	sclerocornea	"a congenital anomaly of the eye in which partial or complete corneal opacity is present and resembles the sclera, with no clear boundary between these structures" [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025225	Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*	/ reaction
ENSMUSG00000024927	Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*	/ reaction
ENSMUSG00000028163	Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr