5970


Homo sapiens (NCBI)

Features
Gene ID: 5970
  
Biological name :
  
Synonyms : NFKB3|p65 / RELA / RELA proto-oncogene, NF-kB subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 201783_s_at (Human Genome U133 Plus 2.0 Array)   209878_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 223468676
RefSeq - 223468681
RefSeq - 345842443
RefSeq - 345842445
RefSeq - 767968615
RefSeq - 767968617
RefSeq - NC_000011.10
RefSeq - NG_029971.1
RefSeq - NP_001138610.1
RefSeq - NP_001230913.1
RefSeq - NP_001230914.1
RefSeq - NP_068810.3
RefSeq - XP_011543508.1
RefSeq - XP_011543509.1
RefSeq - NM_001145138.1
RefSeq - NM_001243984.1
RefSeq - NM_001243985.1
RefSeq - NM_021975.3
RefSeq - XM_011545206.2
RefSeq - XM_011545207.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000173039 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006117 acetaldehyde metabolic process IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0006968 cellular defense response NAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010224 response to UV-B IDA
 biological_processGO:0014040 positive regulation of Schwann cell differentiation IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis TAS
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0032495 response to muramyl dipeptide IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0033234 negative regulation of protein sumoylation IEA
 biological_processGO:0033590 response to cobalamin IEA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IMP
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IBA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043620 regulation of DNA-templated transcription in response to stress IMP
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050727 regulation of inflammatory response ISS
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051607 defense response to virus NAS
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0070555 response to interleukin-1 IGI
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IMP
 biological_processGO:0071224 cellular response to peptidoglycan IMP
 biological_processGO:0071316 cellular response to nicotine IMP
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0071354 cellular response to interleukin-6 IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling IGI
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IMP
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:1904385 cellular response to angiotensin IMP
 biological_processGO:2000630 positive regulation of miRNA metabolic process IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 cellular_componentGO:0035525 NF-kappaB p50/p65 complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IMP
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0042301 phosphate ion binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0042805 actinin binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0051059 NF-kappaB binding IPI
 molecular_functionGO:0070491 repressing transcription factor binding IPI
 molecular_functionGO:0071532 ankyrin repeat binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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