ENSMUSG00000028760


Mus musculus

Features
Gene ID: ENSMUSG00000028760
  
Biological name :Eif4g3
  
Synonyms : Eif4g3 / Mus musculus eukaryotic translation initiation factor 4 gamma, 3 (Eif4g3), transcript variant 4, mRNA.
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 4 gamma 3 / O43432
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 137993022
Gene end: 138208508
  
Corresponding Affymetrix probe sets: 10509463 (MoGene1.0st)   1426833_at (Mouse Genome 430 2.0 Array)   1430578_at (Mouse Genome 430 2.0 Array)   1440571_at (Mouse Genome 430 2.0 Array)   1446145_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081233
Ensembl peptide - ENSMUSP00000081232
Ensembl peptide - ENSMUSP00000101456
Ensembl peptide - ENSMUSP00000145147
Ensembl peptide - ENSMUSP00000122972
Ensembl peptide - ENSMUSP00000116927
Ensembl peptide - ENSMUSP00000115946
Ensembl peptide - ENSMUSP00000101457
Ensembl peptide - ENSMUSP00000059465
NCBI entrez gene - 230861     See in Manteia.
MGI - MGI:1923935
RefSeq - XM_006538797
RefSeq - XM_006538798
RefSeq - XM_011250234
RefSeq - XM_017320161
RefSeq - XM_017320162
RefSeq - XM_017320163
RefSeq - XM_017320164
RefSeq - XM_017320165
RefSeq - XM_017320166
RefSeq - XM_017320167
RefSeq - XM_017320168
RefSeq - XM_017320170
RefSeq - XM_017320171
RefSeq - XM_017320172
RefSeq - NM_001256195
RefSeq - NM_001256198
RefSeq - NM_001355699
RefSeq - NM_172703
RefSeq - XM_006538770
RefSeq - XM_006538771
RefSeq - XM_006538772
RefSeq - XM_006538773
RefSeq - XM_006538774
RefSeq - XM_006538775
RefSeq - XM_006538776
RefSeq - XM_006538778
RefSeq - XM_006538779
RefSeq - XM_006538780
RefSeq - XM_006538783
RefSeq - XM_006538785
RefSeq - XM_006538787
RefSeq - XM_006538788
RefSeq - XM_006538789
RefSeq - XM_006538790
RefSeq - XM_006538791
RefSeq - XM_006538792
RefSeq - XM_006538793
RefSeq - XM_006538794
RefSeq - XM_006538795
RefSeq Peptide - NP_001342628
RefSeq Peptide - NP_766291
RefSeq Peptide - NP_001243124
RefSeq Peptide - NP_001243127
swissprot - A2AMI2
swissprot - A0A0R4J112
swissprot - A2AMI7
swissprot - Q8BQR8
swissprot - Z4YKC4
swissprot - A0A0N4SVL0
swissprot - A2AMI6
swissprot - A2AMI4
swissprot - A2AMI3
Ensembl - ENSMUSG00000028760
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4g3aENSDARG00000077215Danio rerio
 eif4g3bENSDARG00000074331Danio rerio
 EIF4G3ENSGALG00000010084Gallus gallus
 EIF4G3ENSG00000075151Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*ENSMUSG0000004598347
Eif4g2 / eukaryotic translation initiation factor 4 gamma 2 isoform 2 / P78344* / eukaryotic translation initiation factor 4 gamma 2*ENSMUSG0000000561015


Protein motifs (from Interpro)
Interpro ID Name
 IPR003307  W2 domain
 IPR003890  MIF4G-like, type 3
 IPR003891  Initiation factor eIF-4 gamma, MA3
 IPR016024  Armadillo-type fold
 IPR037585  Eukaryotic translation initiation factor 4 gamma 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006413 translational initiation IEA
 molecular_functionGO:0000339 RNA cap binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Rom1Rgsc1156/Rom1Rgsc1156
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rom1Rgsc1156/Rom1Rgsc1156
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rom1Rgsc1156/Rom1Rgsc1156
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Eif4g3Gt(XC431)Byg/Eif4g3repro8
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rom1Rgsc1156/Rom1Rgsc1156
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Eif4g3Gt(XC431)Byg/Eif4g3repro8
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rom1Rgsc1156/Rom1Rgsc1156
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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