ENSG00000075151


Homo sapiens

Features
Gene ID: ENSG00000075151
  
Biological name :EIF4G3
  
Synonyms : EIF4G3 / eukaryotic translation initiation factor 4 gamma 3 / O43432
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.12
Gene start: 20806292
Gene end: 21176888
  
Corresponding Affymetrix probe sets: 1554309_at (Human Genome U133 Plus 2.0 Array)   1554310_a_at (Human Genome U133 Plus 2.0 Array)   201935_s_at (Human Genome U133 Plus 2.0 Array)   201936_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000383274
Ensembl peptide - ENSP00000364071
Ensembl peptide - ENSP00000395381
Ensembl peptide - ENSP00000489051
Ensembl peptide - ENSP00000473510
Ensembl peptide - ENSP00000396083
Ensembl peptide - ENSP00000264211
Ensembl peptide - ENSP00000349386
NCBI entrez gene - 8672     See in Manteia.
OMIM - 603929
RefSeq - XM_017002712
RefSeq - XM_017002701
RefSeq - XM_017002702
RefSeq - XM_017002703
RefSeq - XM_017002704
RefSeq - XM_017002705
RefSeq - XM_017002706
RefSeq - XM_017002707
RefSeq - XM_017002708
RefSeq - XM_017002709
RefSeq - NM_001198801
RefSeq - NM_001198802
RefSeq - NM_001198803
RefSeq - NM_003760
RefSeq - XM_011542356
RefSeq - XM_011542361
RefSeq - XM_011542370
RefSeq - XM_011542371
RefSeq - XM_011542374
RefSeq - XM_011542375
RefSeq - XM_011542381
RefSeq - XM_017002672
RefSeq - XM_017002673
RefSeq - XM_017002674
RefSeq - XM_017002675
RefSeq - XM_017002676
RefSeq - XM_017002677
RefSeq - XM_017002678
RefSeq - XM_017002679
RefSeq - XM_017002680
RefSeq - XM_017002681
RefSeq - XM_017002682
RefSeq - XM_017002683
RefSeq - XM_017002684
RefSeq - XM_017002685
RefSeq - XM_017002686
RefSeq - XM_017002687
RefSeq - XM_017002688
RefSeq - XM_017002689
RefSeq - XM_017002690
RefSeq - XM_017002691
RefSeq - XM_017002692
RefSeq - XM_017002693
RefSeq - XM_017002694
RefSeq - XM_017002695
RefSeq - XM_017002696
RefSeq - XM_017002697
RefSeq - XM_017002698
RefSeq - XM_017002699
RefSeq - XM_017002700
RefSeq Peptide - NP_001185731
RefSeq Peptide - NP_001185732
RefSeq Peptide - NP_003751
RefSeq Peptide - NP_001185730
swissprot - B1AN92
swissprot - O43432
swissprot - B1AN91
swissprot - A0A0U1RQK7
swissprot - A0A0A0MSA7
Ensembl - ENSG00000075151
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4g3aENSDARG00000077215Danio rerio
 eif4g3bENSDARG00000074331Danio rerio
 EIF4G3ENSGALG00000010084Gallus gallus
 Eif4g3ENSMUSG00000028760Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1ENSG0000011486748
EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2ENSG0000011032115


Protein motifs (from Interpro)
Interpro ID Name
 IPR003307  W2 domain
 IPR003890  MIF4G-like, type 3
 IPR003891  Initiation factor eIF-4 gamma, MA3
 IPR016024  Armadillo-type fold
 IPR037585  Eukaryotic translation initiation factor 4 gamma 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation TAS
 biological_processGO:0016032 viral process IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex TAS
 molecular_functionGO:0000339 RNA cap binding TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008135 translation factor activity, RNA binding TAS


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / complex
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / complex
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / complex
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / complex
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / complex
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction






 

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