ENSG00000166233


Homo sapiens

Features
Gene ID: ENSG00000166233
  
Biological name :ARIH1
  
Synonyms : ariadne RBR E3 ubiquitin protein ligase 1 / ARIH1 / Q9Y4X5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q24.1
Gene start: 72474326
Gene end: 72602985
  
Corresponding Affymetrix probe sets: 1558401_at (Human Genome U133 Plus 2.0 Array)   201878_at (Human Genome U133 Plus 2.0 Array)   201879_at (Human Genome U133 Plus 2.0 Array)   201880_at (Human Genome U133 Plus 2.0 Array)   201881_s_at (Human Genome U133 Plus 2.0 Array)   241658_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369217
Ensembl peptide - ENSP00000456746
Ensembl peptide - ENSP00000457767
Ensembl peptide - ENSP00000477687
Ensembl peptide - ENSP00000454774
NCBI entrez gene - 25820     See in Manteia.
OMIM - 605624
RefSeq - XM_011521439
RefSeq - NM_005744
RefSeq - XM_011521438
RefSeq Peptide - NP_005735
swissprot - H3BUS0
swissprot - A0A087WT96
swissprot - Q9Y4X5
swissprot - H3BNB9
swissprot - H3BSK4
Ensembl - ENSG00000166233
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arih1ENSDARG00000003616Danio rerio
 arih1lENSDARG00000036870Danio rerio
 ARIH1ENSGALG00000001901Gallus gallus
 Arih1ENSMUSG00000025234Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARIH2 / O95376 / ariadne RBR E3 ubiquitin protein ligase 2ENSG0000017747930
ANKIB1 / Q9P2G1 / ankyrin repeat and IBR domain containing 1ENSG0000000162928


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR002867  IBR domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR031127  E3 ubiquitin ligase RBR family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0000151 ubiquitin ligase complex TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IDA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IDA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA
 cellular_componentGO:0097413 Lewy body IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019787 ubiquitin-like protein transferase activity TAS
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction / complex
 ENSG00000170142 P51965 / UBE2E1 / ubiquitin conjugating enzyme E2 E1  / reaction
 ENSG00000138032 PPM1B / O75688 / protein phosphatase, Mg2+/Mn2+ dependent 1B  / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction / complex
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / reaction
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / reaction
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / reaction
 ENSG00000075151 EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3  / reaction
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / reaction
 ENSG00000136068 FLNB / O75369 / filamin B  / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction / complex
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / reaction
 ENSG00000110321 EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2  / reaction






 

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