ENSG00000163412


Homo sapiens

Features
Gene ID: ENSG00000163412
  
Biological name :EIF4E3
  
Synonyms : EIF4E3 / eukaryotic translation initiation factor 4E family member 3 / Q8N5X7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p13
Gene start: 71675416
Gene end: 71754773
  
Corresponding Affymetrix probe sets: 225939_at (Human Genome U133 Plus 2.0 Array)   225940_at (Human Genome U133 Plus 2.0 Array)   225941_at (Human Genome U133 Plus 2.0 Array)   238461_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411762
Ensembl peptide - ENSP00000410350
Ensembl peptide - ENSP00000417889
Ensembl peptide - ENSP00000419421
Ensembl peptide - ENSP00000418211
Ensembl peptide - ENSP00000295612
Ensembl peptide - ENSP00000374476
Ensembl peptide - ENSP00000393324
NCBI entrez gene - 317649     See in Manteia.
OMIM - 609896
RefSeq - XM_017006282
RefSeq - NM_001134650
RefSeq - NM_001134651
RefSeq - NM_001282886
RefSeq - NM_173359
RefSeq - XM_011533651
RefSeq - XM_017006278
RefSeq - XM_017006279
RefSeq - XM_017006280
RefSeq - XM_017006281
RefSeq - NM_001134649
RefSeq Peptide - NP_001128122
RefSeq Peptide - NP_001128123
RefSeq Peptide - NP_001269815
RefSeq Peptide - NP_775495
RefSeq Peptide - NP_001128121
swissprot - C9J7Z6
swissprot - Q8N5X7
swissprot - C9J6E5
swissprot - C9JUY2
Ensembl - ENSG00000163412
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4e3ENSDARG00000005078Danio rerio
 EIF4E3ENSGALG00000007780Gallus gallus
 Eif4e3ENSMUSG00000093661Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4E / P06730 / eukaryotic translation initiation factor 4EENSG0000015124726
EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2ENSG0000013593025
A6NMX2 / EIF4E1B / eukaryotic translation initiation factor 4E family member 1BENSG0000017576623


Protein motifs (from Interpro)
Interpro ID Name
 IPR001040  Translation Initiation factor eIF- 4e
 IPR023398  Translation Initiation factor eIF- 4e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005845 mRNA cap binding complex ISS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / reaction
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / complex
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / complex
 ENSG00000075151 EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3  / complex
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / complex
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / complex
 ENSG00000110321 EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2  / complex
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction






 

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