ENSG00000110321


Homo sapiens

Features
Gene ID: ENSG00000110321
  
Biological name :EIF4G2
  
Synonyms : EIF4G2 / eukaryotic translation initiation factor 4 gamma 2 / P78344
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.4
Gene start: 10797050
Gene end: 10809110
  
Corresponding Affymetrix probe sets: 1557964_at (Human Genome U133 Plus 2.0 Array)   200004_at (Human Genome U133 Plus 2.0 Array)   217607_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433335
Ensembl peptide - ENSP00000340281
Ensembl peptide - ENSP00000379778
Ensembl peptide - ENSP00000431511
Ensembl peptide - ENSP00000431583
Ensembl peptide - ENSP00000433121
Ensembl peptide - ENSP00000433217
Ensembl peptide - ENSP00000433371
Ensembl peptide - ENSP00000433561
Ensembl peptide - ENSP00000433664
Ensembl peptide - ENSP00000434815
Ensembl peptide - ENSP00000434940
Ensembl peptide - ENSP00000435220
Ensembl peptide - ENSP00000435523
Ensembl peptide - ENSP00000435912
Ensembl peptide - ENSP00000436235
Ensembl peptide - ENSP00000436680
Ensembl peptide - ENSP00000492820
NCBI entrez gene - 1982     See in Manteia.
OMIM - 602325
RefSeq - NM_001042559
RefSeq - NM_001418
RefSeq - NM_001172705
RefSeq Peptide - NP_001036024
RefSeq Peptide - NP_001166176
RefSeq Peptide - NP_001409
swissprot - D3DQV9
swissprot - E9PKF8
swissprot - H0YD77
swissprot - H0YD99
swissprot - H0YDC0
swissprot - H0YE22
swissprot - H0YE44
swissprot - H0YE87
swissprot - H0YCH5
swissprot - H0YEC5
swissprot - H0YEI7
swissprot - H0YEN8
swissprot - H0YEW3
swissprot - H0YCF8
swissprot - H0Y3P2
swissprot - P78344
Ensembl - ENSG00000110321
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4g2aENSDARG00000020377Danio rerio
 eif4g2bENSDARG00000057167Danio rerio
 EIF4G2ENSGALG00000005587Gallus gallus
 Eif4g2ENSMUSG00000005610Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1ENSG0000011486728
EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3ENSG0000007515127


Protein motifs (from Interpro)
Interpro ID Name
 IPR003307  W2 domain
 IPR003890  MIF4G-like, type 3
 IPR003891  Initiation factor eIF-4 gamma, MA3
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation IDA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008219 cell death TAS
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0034645 cellular macromolecule biosynthetic process IGI
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex IDA
 cellular_componentGO:0030424 axon IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008135 translation factor activity, RNA binding IDA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / reaction
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / complex
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / complex
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / complex
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / complex
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / complex
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction






 

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