ENSG00000187608


Homo sapiens

Features
Gene ID: ENSG00000187608
  
Biological name :ISG15
  
Synonyms : ISG15 / ISG15 ubiquitin-like modifier / P05161
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.33
Gene start: 1001138
Gene end: 1014541
  
Corresponding Affymetrix probe sets: 205483_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368699
Ensembl peptide - ENSP00000485643
Ensembl peptide - ENSP00000485313
NCBI entrez gene - 9636     See in Manteia.
OMIM - 147571
RefSeq - NM_005101
RefSeq Peptide - NP_005092
swissprot - A0A096LPJ4
swissprot - A0A096LNZ9
swissprot - P05161
Ensembl - ENSG00000187608
  
Related genetic diseases (OMIM): 616126 - Immunodeficiency 38, 616126
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 isg15ENSDARG00000086374Danio rerio
 Isg15ENSMUSG00000035692Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBC / P0CG48 / ubiquitin CENSG0000015099121
UBB / P0CG47 / ubiquitin BENSG0000017031519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR019956  Ubiquitin
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019941 modification-dependent protein catabolic process IEA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IDA
 biological_processGO:0032020 ISG15-protein conjugation IMP
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0032649 regulation of interferon-gamma production IMP
 biological_processGO:0034340 response to type I interferon IDA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060337 type I interferon signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031386 protein tag IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Interferon alpha/beta signaling
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
Show

 HP:0002721 Immunodeficiency 
Show

 HP:0011274 Recurrent mycobacterial infections "Increased susceptibility to mycobacterial infections, as manifested by recurrent episodes of mycobacterial infection." [HPO:probinson]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000101751 POLI / Q9UNA4 / DNA polymerase iota  / reaction
 ENSG00000122008 POLK / Q9UBT6 / DNA polymerase kappa  / reaction
 ENSG00000135945 REV1 / Q9UBZ9 / REV1, DNA directed polymerase  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / complex / reaction
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction / complex
 ENSG00000170142 P51965 / UBE2E1 / ubiquitin conjugating enzyme E2 E1  / reaction / complex
 ENSG00000154914 USP43 / Q70EL4 / ubiquitin specific peptidase 43  / reaction / complex
 ENSG00000136068 FLNB / O75369 / filamin B  / complex / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction / complex
 ENSG00000138032 PPM1B / O75688 / protein phosphatase, Mg2+/Mn2+ dependent 1B  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / reaction / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000182179 UBA7 / P41226 / ubiquitin like modifier activating enzyme 7  / reaction / complex
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction
 ENSG00000069869 NEDD4 / P46934 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000170734 POLH / Q9Y253 / DNA polymerase eta  / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / reaction
 ENSG00000110321 EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2  / reaction
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / reaction
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / complex / reaction
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / reaction
 ENSG00000075151 EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3  / reaction
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr