ENSG00000101751


Homo sapiens

Features
Gene ID: ENSG00000101751
  
Biological name :POLI
  
Synonyms : DNA polymerase iota / POLI / Q9UNA4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q21.2
Gene start: 54269404
Gene end: 54321266
  
Corresponding Affymetrix probe sets: 219317_at (Human Genome U133 Plus 2.0 Array)   238992_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464025
Ensembl peptide - ENSP00000463071
Ensembl peptide - ENSP00000463971
Ensembl peptide - ENSP00000217800
Ensembl peptide - ENSP00000385196
Ensembl peptide - ENSP00000461983
Ensembl peptide - ENSP00000462146
Ensembl peptide - ENSP00000462664
Ensembl peptide - ENSP00000462681
Ensembl peptide - ENSP00000463065
NCBI entrez gene - 11201     See in Manteia.
OMIM - 605252
RefSeq - NM_001351632
RefSeq - NM_001351610
RefSeq - NM_001351611
RefSeq - NM_001351612
RefSeq - NM_001351614
RefSeq - NM_001351615
RefSeq - NM_001351617
RefSeq - NM_001351618
RefSeq - NM_001351619
RefSeq - NM_007195
RefSeq - XM_005258188
RefSeq - XM_005258192
RefSeq - XM_006722378
RefSeq - XM_011525796
RefSeq - XM_011525797
RefSeq Peptide - NP_001338540
RefSeq Peptide - NP_001338541
RefSeq Peptide - NP_001338539
RefSeq Peptide - NP_001338543
RefSeq Peptide - NP_001338544
RefSeq Peptide - NP_001338546
RefSeq Peptide - NP_001338547
RefSeq Peptide - NP_001338548
RefSeq Peptide - NP_001338561
RefSeq Peptide - NP_009126
swissprot - J3KTN3
swissprot - J3KQ09
swissprot - X6R2I3
swissprot - J3KRG0
swissprot - J3KRS8
swissprot - J3KSW2
swissprot - J3KTM8
swissprot - Q9UNA4
swissprot - J3QQZ8
swissprot - J3QR36
Ensembl - ENSG00000101751
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 poliENSDARG00000029250Danio rerio
 PoliENSMUSG00000038425Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
REV1 / Q9UBZ9 / REV1, DNA directed polymeraseENSG0000013594521
POLH / Q9Y253 / DNA polymerase etaENSG0000017073421
POLK / Q9UBT6 / DNA polymerase kappaENSG0000012200818


Protein motifs (from Interpro)
Interpro ID Name
 IPR001126  UmuC domain
 IPR017061  DNA polymerase eta/kappa/iota/IV
 IPR017961  DNA polymerase, Y-family, little finger domain
 IPR036775  DNA polymerase, Y-family, little finger domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0042276 error-prone translesion synthesis TAS
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by POLI
Termination of translesion DNA synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000182179 UBA7 / P41226 / ubiquitin like modifier activating enzyme 7  / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000009413 REV3L / O60673 / REV3 like, DNA directed polymerase zeta catalytic subunit  / reaction / complex
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction / complex
 ENSG00000116670 MAD2L2 / Q9UI95 / mitotic arrest deficient 2 like 2  / reaction / complex
 ENSG00000135945 REV1 / Q9UBZ9 / REV1, DNA directed polymerase  / complex / reaction






 

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