ENSMUSG00000038425


Mus musculus

Features
Gene ID: ENSMUSG00000038425
  
Biological name :Poli
  
Synonyms : Poli / polymerase (DNA directed), iota
  
Possible biological names infered from orthology : DNA polymerase iota / Q9UNA4
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E2
Gene start: 70508680
Gene end: 70530620
  
Corresponding Affymetrix probe sets: 10459655 (MoGene1.0st)   1449098_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125467
Ensembl peptide - ENSMUSP00000039869
Ensembl peptide - ENSMUSP00000112563
Ensembl peptide - ENSMUSP00000123964
Ensembl peptide - ENSMUSP00000124877
NCBI entrez gene - 26447     See in Manteia.
MGI - MGI:1347081
RefSeq - XM_017317911
RefSeq - NM_001289515
RefSeq - NM_001289516
RefSeq - NM_011972
RefSeq - XM_006525945
RefSeq - XM_006525946
RefSeq - XM_011246933
RefSeq - XM_011246934
RefSeq - XM_017317910
RefSeq - NM_001136090
RefSeq Peptide - NP_001129562
RefSeq Peptide - NP_001276444
RefSeq Peptide - NP_001276445
RefSeq Peptide - NP_036102
swissprot - A0A0R4J1Z5
swissprot - E9Q3H9
swissprot - E0CZD6
swissprot - E9QJU6
Ensembl - ENSMUSG00000038425
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 poliENSDARG00000029250Danio rerio
 POLIENSG00000101751Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*ENSMUSG0000002395320
Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*ENSMUSG0000002166819
Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*ENSMUSG0000002608219


Protein motifs (from Interpro)
Interpro ID Name
 IPR001126  UmuC domain
 IPR017061  DNA polymerase eta/kappa/iota/IV
 IPR017961  DNA polymerase, Y-family, little finger domain
 IPR024728  DNA polymerase type-Y, HhH motif
 IPR036775  DNA polymerase, Y-family, little finger domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0003684 damaged DNA binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by POLI
Termination of translesion DNA synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Polhtm2Fmh/Polh+
Genetic Background: B6.129-Polhtm2Fmh

Allelic Composition: Polhtm2Fmh/Polhtm2Fmh,Polid/Poli+
Genetic Background: B6.129-Polhtm2Fmh Polid

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polhtm1Crey/Polhtm1Crey,Polid/Polid
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epcamtm1.2Msiv/Epcamtm1.2Msiv
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Pas17C57BL/6JBy/Pas17C57BL/6JBy,Politm1.1Lgh/Poli+
Genetic Background: involves: C57BL/6J

Allelic Composition: Pas17C57BL/6JBy/Pas17C57BL/6JBy,Politm1.1Lgh/Politm1.1Lgh
Genetic Background: involves: C57BL/6J

Allelic Composition: Politm1.1Lgh/Politm1.1Lgh,Tg(gptdelta)1Nmi/0
Genetic Background: involves: C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pas17C57BL/6JBy/Pas17C57BL/6JBy,Politm1.1Lgh/Poli+
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019841 Rev3l / Q61493 / DNA polymerase zeta catalytic subunit / O60673* / REV3 like, DNA directed polymerase zeta catalytic subunit*  / complex / reaction
 ENSMUSG00000029003 Mad2l2 / Q9D752 / Mitotic spindle assembly checkpoint protein MAD2B / Q9UI95* / mitotic arrest deficient 2 like 2*  / reaction / complex
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction / complex
 ENSMUSG00000026082 Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*  / complex / reaction
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000000275 Q61510 / Trim25 / E3 ubiquitin/ISG15 ligase TRIM25 / Q14258* / tripartite motif containing 25*  / reaction / complex
 ENSMUSG00000032596 Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*  / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr