Manteia - Molecule gene

ENSMUSG00000000275

Mus musculus

Features

Gene ID:	ENSMUSG00000000275

Biological name :	Trim25

Synonyms :	E3 ubiquitin/ISG15 ligase TRIM25 / Q61510 / Trim25

Possible biological names infered from orthology :	Q14258 / tripartite motif containing 25

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	C
Gene start:	88999376
Gene end:	89020293

Corresponding Affymetrix probe sets:	10380260 (MoGene1.0st) 1419879_s_at (Mouse Genome 430 2.0 Array) 1425974_a_at (Mouse Genome 430 2.0 Array) 1426415_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000000284 Ensembl peptide - ENSMUSP00000098192 Ensembl peptide - ENSMUSP00000103528 NCBI entrez gene - 217069 See in Manteia. MGI - MGI:102749 RefSeq - XM_017314476 RefSeq - NM_009546 RefSeq Peptide - NP_033572 swissprot - Q5SU71 swissprot - Q5SU72 swissprot - Q61510 Ensembl - ENSMUSG00000000275

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
trim25	ENSDARG00000104396	Danio rerio
TRIM25	ENSGALG00000003144	Gallus gallus
Q14258	ENSG00000121060	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Trim80 / tripartite motif-containing 80	ENSMUSG00000070332	27
Q8C0E3 / Trim47 / tripartite motif-containing 47 / Q96LD4*	ENSMUSG00000020773	23
Q99PP9 / Trim16 / Tripartite motif-containing protein 16 / Q309B1* / O95361* / TRIM16L* / AC005324.3* / tripartite motif containing 16* / tripartite motif containing 16 like*	ENSMUSG00000047821	21
Q8BFW4 / Trim65 / Tripartite motif-containing protein 65 / Q6PJ69* / tripartite motif containing 65*	ENSMUSG00000054517	17
Q8R2Q0 / Trim29 / Tripartite motif-containing protein 29 / Q14134* / tripartite motif containing 29*	ENSMUSG00000032013	17

Protein motifs (from Interpro)

Interpro ID	Name
IPR001841	Zinc finger, RING-type
IPR001870	B30.2/SPRY domain
IPR003877	SPRY domain
IPR003879	Butyrophylin-like, SPRY domain
IPR006574	SPRY-associated
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
IPR017907	Zinc finger, RING-type, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0006513	protein monoubiquitination	IEA
biological_process	GO:0016567	protein ubiquitination	IEA
biological_process	GO:0030433	ubiquitin-dependent ERAD pathway	IEA
biological_process	GO:0033280	response to vitamin D	IEA
biological_process	GO:0036503	ERAD pathway	IEA
biological_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IEA
biological_process	GO:0043627	response to estrogen	IEA
biological_process	GO:0045087	innate immune response	ISO
biological_process	GO:0046596	regulation of viral entry into host cell	IEA
biological_process	GO:0046597	negative regulation of viral entry into host cell	IDA
biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IEA
biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IEA
biological_process	GO:0051607	defense response to virus	IEA
biological_process	GO:1902186	regulation of viral release from host cell	IEA
biological_process	GO:1902187	negative regulation of viral release from host cell	IDA
biological_process	GO:1990830	cellular response to leukemia inhibitory factor	IEP
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0016604	nuclear body	IEA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	ISO
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016874	ligase activity	IEA
molecular_function	GO:0045296	cadherin binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

ISG15 antiviral mechanism

Termination of translesion DNA synthesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002637	small uterus	"reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Adam15^tm1Bbl/Adam15^tm1Bbl Genetic Background: B6.129X1-Adam15^tm1Bbl
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Trim25^tm1Mura/Trim25⁺,Usp15^L749R/Usp15⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
MP:0005026	decreased susceptibility to parasitic infection	"reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Usp15^L749R/Usp15^tm1Pgrs Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0010751	decreased susceptibility to parasitic infection induced morbidity/mortality	"decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Usp15^L749R/Usp15^tm1Pgrs Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Trim25^tm1Mura/Trim25⁺,Usp15^L749R/Usp15⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000032596	Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*	/ reaction
ENSMUSG00000035692	Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*	/ reaction
ENSMUSG00000000751	Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*	/ reaction / complex
ENSMUSG00000012483	Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*	/ complex / reaction
ENSMUSG00000023953	Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*	/ reaction / complex
ENSMUSG00000021668	Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*	/ reaction / complex
ENSMUSG00000026082	Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*	/ complex / reaction
ENSMUSG00000038425	Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*	/ reaction / complex
ENSMUSG00000027342	Pcna / P17918 / proliferating cell nuclear antigen / P12004*	/ complex / reaction
ENSMUSG00000028884	Rpa2 / replication protein A2 / P15927*	/ reaction / complex
ENSMUSG00000027078	Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr