ENSMUSG00000026082


Mus musculus

Features
Gene ID: ENSMUSG00000026082
  
Biological name :Rev1
  
Synonyms : DNA repair protein REV1 / Q920Q2 / Rev1
  
Possible biological names infered from orthology : Q9UBZ9 / REV1, DNA directed polymerase
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: B
Gene start: 38052786
Gene end: 38129801
  
Corresponding Affymetrix probe sets: 10354085 (MoGene1.0st)   1422624_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141379
Ensembl peptide - ENSMUSP00000027251
Ensembl peptide - ENSMUSP00000141560
Ensembl peptide - ENSMUSP00000141875
Ensembl peptide - ENSMUSP00000141815
Ensembl peptide - ENSMUSP00000141647
NCBI entrez gene - 56210     See in Manteia.
MGI - MGI:1929074
RefSeq - XM_017321836
RefSeq - XM_006496158
RefSeq - XM_006496161
RefSeq - XM_006496162
RefSeq - XM_006496164
RefSeq - XM_017321831
RefSeq - XM_017321833
RefSeq - XM_017321835
RefSeq - NM_019570
RefSeq - XM_006496153
RefSeq - XM_006496154
RefSeq - XM_006496155
RefSeq - XM_006496156
RefSeq Peptide - NP_062516
swissprot - A0A0A6YX32
swissprot - A0A0A6YWQ5
swissprot - A0A0A6YX77
swissprot - A0A0A6YW35
swissprot - Q920Q2
swissprot - A0A0A6YWI0
Ensembl - ENSMUSG00000026082
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rev1ENSDARG00000018296Danio rerio
 REV1ENSGALG00000016766Gallus gallus
 REV1ENSG00000135945Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*ENSMUSG0000002166812
Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*ENSMUSG0000003842511
Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*ENSMUSG0000002395310


Protein motifs (from Interpro)
Interpro ID Name
 IPR001126  UmuC domain
 IPR001357  BRCT domain
 IPR012112  DNA repair protein Rev1
 IPR017961  DNA polymerase, Y-family, little finger domain
 IPR025527  Domain of unknown function DUF4414
 IPR031991  DNA repair protein Rev1, C-terminal
 IPR036420  BRCT domain superfamily
 IPR036775  DNA polymerase, Y-family, little finger domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0042276 error-prone translesion synthesis IDA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0017125 deoxycytidyl transferase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbs/Ednrbs-4Chlc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002223 lymphoid hypoplasia "decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rev1tm1.1Jow/Rev1tm1.1Jow
Genetic Background: involves: C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000019841 Rev3l / Q61493 / DNA polymerase zeta catalytic subunit / O60673* / REV3 like, DNA directed polymerase zeta catalytic subunit*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000029003 Mad2l2 / Q9D752 / Mitotic spindle assembly checkpoint protein MAD2B / Q9UI95* / mitotic arrest deficient 2 like 2*  / complex / reaction
 ENSMUSG00000032596 Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*  / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction / complex
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / reaction
 ENSMUSG00000021668 Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*  / complex / reaction
 ENSMUSG00000000275 Q61510 / Trim25 / E3 ubiquitin/ISG15 ligase TRIM25 / Q14258* / tripartite motif containing 25*  / reaction / complex
 ENSMUSG00000038425 Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*  / reaction / complex






 

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