ENSMUSG00000032596


Mus musculus

Features
Gene ID: ENSMUSG00000032596
  
Biological name :Uba7
  
Synonyms : Uba7 / ubiquitin-like modifier activating enzyme 7
  
Possible biological names infered from orthology : P41226
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 107975505
Gene end: 107984060
  
Corresponding Affymetrix probe sets: 10588786 (MoGene1.0st)   1426970_a_at (Mouse Genome 430 2.0 Array)   1426971_at (Mouse Genome 430 2.0 Array)   1437317_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135584
Ensembl peptide - ENSMUSP00000035216
Ensembl peptide - ENSMUSP00000134910
NCBI entrez gene - 74153     See in Manteia.
MGI - MGI:1349462
RefSeq - NM_023738
RefSeq Peptide - NP_076227
swissprot - Q9DBK7
swissprot - H3BJA7
swissprot - H3BKY9
Ensembl - ENSMUSG00000032596
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uba7ENSDARG00000061222Danio rerio
 UBA7ENSGALG00000036263Gallus gallus
 UBA7ENSG00000182179Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Uba1y / P31254 / ubiquitin-activating enzyme, Chr YENSMUSG0000006905346
Uba1 / Q02053 / ubiquitin-like modifier activating enzyme 1 / P22314*ENSMUSG0000000192445
Uba6 / Q8C7R4 / ubiquitin-like modifier activating enzyme 6 / A0AVT1*ENSMUSG0000003589836


Protein motifs (from Interpro)
Interpro ID Name
 IPR000011  Ubiquitin/SUMO-activating enzyme E1
 IPR000594  THIF-type NAD/FAD binding fold
 IPR018075  Ubiquitin-activating enzyme E1
 IPR018965  Ubiquitin-activating enzyme E1, C-terminal
 IPR019572  Ubiquitin-activating enzyme, catalytic cysteine domain
 IPR032418  Ubiquitin-activating enzyme E1, FCCH domain
 IPR032420  Ubiquitin-activating enzyme E1, four-helix bundle
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process ISO
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019941 modification-dependent protein catabolic process IDA
 biological_processGO:0032020 ISG15-protein conjugation ISO
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004839 ubiquitin activating enzyme activity IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0019782 ISG15 activating enzyme activity ISO


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Termination of translesion DNA synthesis
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000275 Q61510 / Trim25 / E3 ubiquitin/ISG15 ligase TRIM25 / Q14258* / tripartite motif containing 25*  / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction
 ENSMUSG00000023953 Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*  / reaction
 ENSMUSG00000021668 Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*  / reaction
 ENSMUSG00000026082 Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*  / reaction
 ENSMUSG00000038425 Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*  / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction
 ENSMUSG00000032596 Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*  / reaction
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr