ENSMUSG00000001924


Mus musculus

Features
Gene ID: ENSMUSG00000001924
  
Biological name :Uba1
  
Synonyms : Q02053 / Uba1 / ubiquitin-like modifier activating enzyme 1
  
Possible biological names infered from orthology : P22314
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.3
Gene start: 20658326
Gene end: 20683179
  
Corresponding Affymetrix probe sets: 10598882 (MoGene1.0st)   1442767_s_at (Mouse Genome 430 2.0 Array)   1448116_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001989
Ensembl peptide - ENSMUSP00000086626
NCBI entrez gene - 22201     See in Manteia.
MGI - MGI:98890
RefSeq - NM_001276317
RefSeq - NM_001136085
RefSeq - NM_001276316
RefSeq - NM_009457
RefSeq Peptide - NP_001129557
RefSeq Peptide - NP_001263245
RefSeq Peptide - NP_001263246
RefSeq Peptide - NP_033483
swissprot - Q02053
swissprot - B9EHN0
Ensembl - ENSMUSG00000001924
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uba1ENSDARG00000037559Danio rerio
 UBA1ENSG00000130985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Uba1y / P31254 / ubiquitin-activating enzyme, Chr YENSMUSG0000006905383
Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*ENSMUSG0000003259642
Uba6 / Q8C7R4 / ubiquitin-like modifier activating enzyme 6 / A0AVT1*ENSMUSG0000003589841


Protein motifs (from Interpro)
Interpro ID Name
 IPR000011  Ubiquitin/SUMO-activating enzyme E1
 IPR000594  THIF-type NAD/FAD binding fold
 IPR018074  Ubiquitin-activating enzyme E1, conserved site
 IPR018075  Ubiquitin-activating enzyme E1
 IPR018965  Ubiquitin-activating enzyme E1, C-terminal
 IPR019572  Ubiquitin-activating enzyme, catalytic cysteine domain
 IPR032418  Ubiquitin-activating enzyme E1, FCCH domain
 IPR032420  Ubiquitin-activating enzyme E1, four-helix bundle
 IPR033127  Ubiquitin-activating enzyme E1, Cys active site
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0000792 heterochromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0030057 desmosome ISO
 cellular_componentGO:0030867 rough endoplasmic reticulum membrane ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004839 ubiquitin activating enzyme activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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