| MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0000818 | abnormal amygdala morphology | "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0001360 | abnormal social investigation | "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0001438 | aphagia | "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0001447 | abnormal nest building behavior | "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0001488 | increased startle reflex | "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0001492 | piloerection | "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm10(Gata2)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
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| MP:0002797 | thigmotaxis | "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0003360 | depression-related behavior | |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0003858 | enhanced coordination | "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0004889 | increased energy expenditure | "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0005266 | abnormal metabolism | "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0005289 | increased oxygen consumption | "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0008267 | abnormal hippocampus CA3 region morphology | |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0008428 | abnormal spatial working memory | "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0008963 | increased carbon dioxide production | "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0009142 | decreased prepulse inhibition | "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0009454 | impaired contextual conditioning | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0009674 | decreased birth weight | "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0009936 | abnormal dendritic spine morphology | "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
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| MP:0011620 | abnormal habituation to a new environment | "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith] |
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: FVB/N
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