ENSG00000033178


Homo sapiens

Features
Gene ID: ENSG00000033178
  
Biological name :UBA6
  
Synonyms : A0AVT1 / UBA6 / ubiquitin like modifier activating enzyme 6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q13.2
Gene start: 67612652
Gene end: 67701179
  
Corresponding Affymetrix probe sets: 1555441_at (Human Genome U133 Plus 2.0 Array)   218340_s_at (Human Genome U133 Plus 2.0 Array)   220869_at (Human Genome U133 Plus 2.0 Array)   222600_s_at (Human Genome U133 Plus 2.0 Array)   222601_at (Human Genome U133 Plus 2.0 Array)   222602_at (Human Genome U133 Plus 2.0 Array)   242834_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000313454
Ensembl peptide - ENSP00000425091
Ensembl peptide - ENSP00000421984
Ensembl peptide - ENSP00000399234
NCBI entrez gene - 55236     See in Manteia.
OMIM - 611361
RefSeq - NM_018227
RefSeq - XM_017008359
RefSeq Peptide - NP_060697
swissprot - H0Y9U5
swissprot - A0A024RDB0
swissprot - H0Y8S8
swissprot - A0AVT1
Ensembl - ENSG00000033178
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-82j4.2ENSDARG00000080019Danio rerio
 UBA6ENSGALG00000011762Gallus gallus
 Uba6ENSMUSG00000035898Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBA1 / P22314 / ubiquitin like modifier activating enzyme 1ENSG0000013098541
UBA7 / P41226 / ubiquitin like modifier activating enzyme 7ENSG0000018217935


Protein motifs (from Interpro)
Interpro ID Name
 IPR000011  Ubiquitin/SUMO-activating enzyme E1
 IPR000594  THIF-type NAD/FAD binding fold
 IPR018075  Ubiquitin-activating enzyme E1
 IPR018965  Ubiquitin-activating enzyme E1, C-terminal
 IPR019572  Ubiquitin-activating enzyme, catalytic cysteine domain
 IPR032418  Ubiquitin-activating enzyme E1, FCCH domain
 IPR032420  Ubiquitin-activating enzyme E1, four-helix bundle
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0021764 amygdala development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0060996 dendritic spine development IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004839 ubiquitin activating enzyme activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0016881 acid-amino acid ligase activity IEA
 molecular_functionGO:0019780 FAT10 activating enzyme activity IMP


Pathways (from Reactome)
Pathway description
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr