ENSG00000122008


Homo sapiens

Features
Gene ID: ENSG00000122008
  
Biological name :POLK
  
Synonyms : DNA polymerase kappa / POLK / Q9UBT6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.3
Gene start: 75511756
Gene end: 75601144
  
Corresponding Affymetrix probe sets: 1555317_at (Human Genome U133 Plus 2.0 Array)   223260_s_at (Human Genome U133 Plus 2.0 Array)   223261_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423526
Ensembl peptide - ENSP00000426853
Ensembl peptide - ENSP00000425208
Ensembl peptide - ENSP00000425075
Ensembl peptide - ENSP00000424859
Ensembl peptide - ENSP00000424174
Ensembl peptide - ENSP00000423532
Ensembl peptide - ENSP00000241436
Ensembl peptide - ENSP00000420997
Ensembl peptide - ENSP00000421879
Ensembl peptide - ENSP00000421997
Ensembl peptide - ENSP00000422094
NCBI entrez gene - 51426     See in Manteia.
OMIM - 605650
RefSeq - XM_017009564
RefSeq - XM_011543467
RefSeq - XM_017009558
RefSeq - XM_017009559
RefSeq - XM_017009560
RefSeq - XM_017009561
RefSeq - XM_017009562
RefSeq - XM_017009563
RefSeq - NM_016218
RefSeq - XM_005248534
RefSeq - XM_011543463
RefSeq - XM_011543464
RefSeq Peptide - NP_057302
swissprot - D6R9M8
swissprot - A0A024RAP4
swissprot - D6RAE5
swissprot - D6RDX9
swissprot - Q9UBT6
swissprot - D6RAI7
Ensembl - ENSG00000122008
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polkENSDARG00000059963Danio rerio
 POLKENSGALG00000014956Gallus gallus
 PolkENSMUSG00000021668Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
REV1 / Q9UBZ9 / REV1, DNA directed polymeraseENSG0000013594518
POLH / Q9Y253 / DNA polymerase etaENSG0000017073415
POLI / Q9UNA4 / DNA polymerase iotaENSG0000010175115


Protein motifs (from Interpro)
Interpro ID Name
 IPR001126  UmuC domain
 IPR006642  Zinc finger, Rad18-type putative
 IPR017061  DNA polymerase eta/kappa/iota/IV
 IPR017961  DNA polymerase, Y-family, little finger domain
 IPR022880  DNA polymerase IV
 IPR024728  DNA polymerase type-Y, HhH motif
 IPR036775  DNA polymerase, Y-family, little finger domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0042276 error-prone translesion synthesis IDA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0090734 site of DNA damage IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by POLK
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000182179 UBA7 / P41226 / ubiquitin like modifier activating enzyme 7  / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction
 ENSG00000116670 MAD2L2 / Q9UI95 / mitotic arrest deficient 2 like 2  / complex / reaction
 ENSG00000005156 LIG3 / P49916 / DNA ligase 3  / reaction
 ENSG00000073050 XRCC1 / P18887 / X-ray repair cross complementing 1  / reaction
 ENSG00000135945 REV1 / Q9UBZ9 / REV1, DNA directed polymerase  / reaction / complex
 ENSG00000105486 LIG1 / P18858 / DNA ligase 1  / reaction
 ENSG00000009413 REV3L / O60673 / REV3 like, DNA directed polymerase zeta catalytic subunit  / complex / reaction






 

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