ENSG00000135930


Homo sapiens

Features
Gene ID: ENSG00000135930
  
Biological name :EIF4E2
  
Synonyms : EIF4E2 / eukaryotic translation initiation factor 4E family member 2 / O60573
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.1
Gene start: 232550052
Gene end: 232583644
  
Corresponding Affymetrix probe sets: 209393_s_at (Human Genome U133 Plus 2.0 Array)   213570_at (Human Genome U133 Plus 2.0 Array)   213571_s_at (Human Genome U133 Plus 2.0 Array)   226734_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386876
Ensembl peptide - ENSP00000386424
Ensembl peptide - ENSP00000386983
Ensembl peptide - ENSP00000390904
Ensembl peptide - ENSP00000389578
Ensembl peptide - ENSP00000387336
Ensembl peptide - ENSP00000387328
Ensembl peptide - ENSP00000386996
Ensembl peptide - ENSP00000258416
NCBI entrez gene - 9470     See in Manteia.
OMIM - 605895
RefSeq - XM_017005377
RefSeq - NM_001276336
RefSeq - NM_001276337
RefSeq - NM_001282958
RefSeq - NM_001330203
RefSeq - NM_004846
RefSeq - XM_005246975
RefSeq - XM_011512206
RefSeq Peptide - NP_001317132
RefSeq Peptide - NP_001263265
RefSeq Peptide - NP_001263266
RefSeq Peptide - NP_001269887
RefSeq Peptide - NP_001317130
RefSeq Peptide - NP_004837
swissprot - B8ZZ50
swissprot - H7BZH2
swissprot - C9JEL3
swissprot - B9A044
swissprot - O60573
swissprot - Q53RG0
swissprot - B4E1E4
swissprot - B9A023
swissprot - B8ZZL3
Ensembl - ENSG00000135930
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4e2ENSDARG00000038585Danio rerio
 EIF4E2ENSGALG00000007919Gallus gallus
 Eif4e2ENSMUSG00000026254Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4E / P06730 / eukaryotic translation initiation factor 4EENSG0000015124730
A6NMX2 / EIF4E1B / eukaryotic translation initiation factor 4E family member 1BENSG0000017576628
EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3ENSG0000016341223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001040  Translation Initiation factor eIF- 4e
 IPR019770  Eukaryotic translation initiation factor 4E (eIF-4E), conserved site
 IPR023398  Translation Initiation factor eIF- 4e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0017148 negative regulation of translation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005845 mRNA cap binding complex IDA
 molecular_functionGO:0000339 RNA cap binding TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008135 translation factor activity, RNA binding TAS
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / complex / reaction
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction / complex
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction / complex
 ENSG00000075151 EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction / complex
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / reaction
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / reaction
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / reaction
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / reaction
 ENSG00000110321 EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2  / reaction






 

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