ENSG00000154914


Homo sapiens

Features
Gene ID: ENSG00000154914
  
Biological name :USP43
  
Synonyms : Q70EL4 / ubiquitin specific peptidase 43 / USP43
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 9644698
Gene end: 9729691
  
Corresponding Affymetrix probe sets: 237439_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000285199
Ensembl peptide - ENSP00000458963
Ensembl peptide - ENSP00000459328
Ensembl peptide - ENSP00000477318
NCBI entrez gene - 124739     See in Manteia.
RefSeq - XM_017024162
RefSeq - NM_001267576
RefSeq - NM_153210
RefSeq - XM_011523641
RefSeq - XM_011523642
RefSeq - XM_017024159
RefSeq - XM_017024160
RefSeq - XM_017024161
RefSeq - XM_011523639
RefSeq - XM_011523640
RefSeq Peptide - NP_694942
RefSeq Peptide - NP_001254505
swissprot - Q70EL4
swissprot - V9GXZ5
swissprot - V9GZ20
Ensembl - ENSG00000154914
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp43aENSDARG00000103494Danio rerio
 usp43bENSDARG00000088072Danio rerio
 ENSGALG00000037812Gallus gallus
 Usp43ENSMUSG00000020905Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP31 / Q70CQ4 / ubiquitin specific peptidase 31ENSG0000010340439
USP19 / O94966 / ubiquitin specific peptidase 19ENSG0000017204619
USP15 / Q9Y4E8 / ubiquitin specific peptidase 15ENSG0000013565517
USP4 / Q13107 / ubiquitin specific peptidase 4ENSG0000011431617
USP32 / Q8NFA0 / ubiquitin specific peptidase 32ENSG0000017083216
USP11 / P51784 / ubiquitin specific peptidase 11ENSG0000010222616
USP6 / P35125 / ubiquitin specific peptidase 6ENSG0000012920415


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0019985 translesion synthesis TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019785 ISG15-specific protease activity TAS
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Termination of translesion DNA synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex






 

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