ENSG00000114316


Homo sapiens

Features
Gene ID: ENSG00000114316
  
Biological name :USP4
  
Synonyms : Q13107 / ubiquitin specific peptidase 4 / USP4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 49277831
Gene end: 49340712
  
Corresponding Affymetrix probe sets: 202681_at (Human Genome U133 Plus 2.0 Array)   202682_s_at (Human Genome U133 Plus 2.0 Array)   211800_s_at (Human Genome U133 Plus 2.0 Array)   244192_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341028
Ensembl peptide - ENSP00000408274
Ensembl peptide - ENSP00000400623
Ensembl peptide - ENSP00000399079
Ensembl peptide - ENSP00000265560
NCBI entrez gene - 7375     See in Manteia.
OMIM - 603486
RefSeq - NM_199443
RefSeq - NM_001251877
RefSeq - NM_003363
RefSeq Peptide - NP_001238806
RefSeq Peptide - NP_003354
RefSeq Peptide - NP_955475
swissprot - Q13107
swissprot - A0A024R2X6
swissprot - A0A024R2T0
swissprot - H7C189
swissprot - C9JNU9
Ensembl - ENSG00000114316
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp4ENSDARG00000014770Danio rerio
 USP4ENSGALG00000003799Gallus gallus
 Usp4ENSMUSG00000032612Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP15 / Q9Y4E8 / ubiquitin specific peptidase 15ENSG0000013565560
USP11 / P51784 / ubiquitin specific peptidase 11ENSG0000010222645
USP32 / Q8NFA0 / ubiquitin specific peptidase 32ENSG0000017083232
USP19 / O94966 / ubiquitin specific peptidase 19ENSG0000017204630
USP6 / P35125 / ubiquitin specific peptidase 6ENSG0000012920426
USP31 / Q70CQ4 / ubiquitin specific peptidase 31ENSG0000010340422
USP43 / Q70EL4 / ubiquitin specific peptidase 43ENSG0000015491420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR018200  Ubiquitin specific protease, conserved site
 IPR026670  Gametogenetin-binding protein 1
 IPR028134  Ubiquitin carboxyl-terminal hydrolase USP4
 IPR028135  Ubiquitin-like domain, USP-type
 IPR028889  Ubiquitin specific protease domain
 IPR035927  DUSP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000244 spliceosomal tri-snRNP complex assembly IMP
 biological_processGO:0000266 mitochondrial fission IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016579 protein deubiquitination IMP
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0031647 regulation of protein stability IDA
 biological_processGO:0034394 protein localization to cell surface IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031685 adenosine receptor binding IPI
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000114316 USP4 / Q13107 / ubiquitin specific peptidase 4  / reaction






 

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