ENSG00000172046


Homo sapiens

Features
Gene ID: ENSG00000172046
  
Biological name :USP19
  
Synonyms : O94966 / ubiquitin specific peptidase 19 / USP19
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 49108046
Gene end: 49120938
  
Corresponding Affymetrix probe sets: 214674_at (Human Genome U133 Plus 2.0 Array)   226357_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000381872
Ensembl peptide - ENSP00000381870
Ensembl peptide - ENSP00000395260
Ensembl peptide - ENSP00000428539
Ensembl peptide - ENSP00000401197
Ensembl peptide - ENSP00000400090
Ensembl peptide - ENSP00000303503
Ensembl peptide - ENSP00000381863
Ensembl peptide - ENSP00000381867
NCBI entrez gene - 10869     See in Manteia.
OMIM - 614471
RefSeq - XM_017005635
RefSeq - XM_017005622
RefSeq - XM_017005623
RefSeq - XM_017005624
RefSeq - XM_017005625
RefSeq - XM_017005626
RefSeq - XM_017005627
RefSeq - XM_017005628
RefSeq - XM_017005629
RefSeq - XM_017005630
RefSeq - XM_017005631
RefSeq - XM_017005632
RefSeq - XM_017005633
RefSeq - XM_017005634
RefSeq - NM_001199160
RefSeq - NM_001199161
RefSeq - NM_001199162
RefSeq - NM_001351099
RefSeq - NM_001351100
RefSeq - NM_001351101
RefSeq - NM_006677
RefSeq - XM_005264823
RefSeq - XM_005264824
RefSeq - XM_005264825
RefSeq - XM_005264826
RefSeq - XM_005264827
RefSeq - XM_005264829
RefSeq - XM_005264830
RefSeq - XM_005264831
RefSeq - XM_006712946
RefSeq - XM_006712947
RefSeq - XM_006712948
RefSeq - XM_006712949
RefSeq - XM_006712950
RefSeq - XM_006712951
RefSeq - XM_006712952
RefSeq - XM_006712953
RefSeq - XM_017005615
RefSeq - XM_017005616
RefSeq - XM_017005617
RefSeq - XM_017005618
RefSeq - XM_017005619
RefSeq - XM_017005620
RefSeq - XM_017005621
RefSeq Peptide - NP_001186090
RefSeq Peptide - NP_001186091
RefSeq Peptide - NP_001338028
RefSeq Peptide - NP_001338029
RefSeq Peptide - NP_001338030
RefSeq Peptide - NP_006668
RefSeq Peptide - NP_001186089
swissprot - E7EST9
swissprot - B5MEG5
swissprot - H0YB23
swissprot - A0A0A0MR08
swissprot - E7ESU0
swissprot - O94966
Ensembl - ENSG00000172046
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp19ENSDARG00000004132Danio rerio
 USP19ENSGALG00000006824Gallus gallus
 Usp19ENSMUSG00000006676Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP11 / P51784 / ubiquitin specific peptidase 11ENSG0000010222620
USP4 / Q13107 / ubiquitin specific peptidase 4ENSG0000011431620
USP32 / Q8NFA0 / ubiquitin specific peptidase 32ENSG0000017083219
USP15 / Q9Y4E8 / ubiquitin specific peptidase 15ENSG0000013565519
USP6 / P35125 / ubiquitin specific peptidase 6ENSG0000012920416
USP31 / Q70CQ4 / ubiquitin specific peptidase 31ENSG0000010340415
USP43 / Q70EL4 / ubiquitin specific peptidase 43ENSG0000015491415


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR002893  Zinc finger, MYND-type
 IPR007052  CS domain
 IPR008978  HSP20-like chaperone
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IMP
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IDA
 biological_processGO:0031647 regulation of protein stability ISS
 biological_processGO:0034976 response to endoplasmic reticulum stress IEP
 biological_processGO:0048642 negative regulation of skeletal muscle tissue development IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:0090068 positive regulation of cell cycle process ISS
 biological_processGO:1900037 regulation of cellular response to hypoxia IMP
 biological_processGO:1901799 negative regulation of proteasomal protein catabolic process IEA
 biological_processGO:1904292 regulation of ERAD pathway IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IDA
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / complex / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / reaction / complex
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / complex / reaction
 ENSG00000164068 Q5XPI4 / RNF123 / ring finger protein 123  / complex






 

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