ENSMUSG00000006676


Mus musculus

Features
Gene ID: ENSMUSG00000006676
  
Biological name :Usp19
  
Synonyms : Q3UJD6 / ubiquitin specific peptidase 19 / Usp19
  
Possible biological names infered from orthology : O94966
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 108490602
Gene end: 108502337
  
Corresponding Affymetrix probe sets: 10588975 (MoGene1.0st)   1424656_s_at (Mouse Genome 430 2.0 Array)   1438812_x_at (Mouse Genome 430 2.0 Array)   1453190_at (Mouse Genome 430 2.0 Array)   1455205_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135930
Ensembl peptide - ENSMUSP00000128573
Ensembl peptide - ENSMUSP00000141628
Ensembl peptide - ENSMUSP00000142137
Ensembl peptide - ENSMUSP00000141826
Ensembl peptide - ENSMUSP00000141738
Ensembl peptide - ENSMUSP00000006854
Ensembl peptide - ENSMUSP00000082119
NCBI entrez gene - 71472     See in Manteia.
MGI - MGI:1918722
RefSeq - XM_017313594
RefSeq - NM_001168371
RefSeq - NM_001168372
RefSeq - NM_001168373
RefSeq - NM_027804
RefSeq - NM_145407
RefSeq - XM_006511832
RefSeq - XM_006511833
RefSeq - XM_006511834
RefSeq - XM_017313593
RefSeq Peptide - NP_001161843
RefSeq Peptide - NP_001161845
RefSeq Peptide - NP_082080
RefSeq Peptide - NP_663382
RefSeq Peptide - NP_001161844
swissprot - A0A0A6YWX1
swissprot - A0A0A6YWN9
swissprot - Q3UJD6
swissprot - E9Q9M5
swissprot - A0A0A6YXT9
swissprot - A0A0A6YX42
swissprot - J3KMM1
Ensembl - ENSMUSG00000006676
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp19ENSDARG00000004132Danio rerio
 USP19ENSGALG00000006824Gallus gallus
 USP19ENSG00000172046Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp4 / P35123 / ubiquitin specific peptidase 4 (proto-oncogene) / Q13107* / ubiquitin specific peptidase 4*ENSMUSG0000003261221
Usp32 / ubiquitin specific peptidase 32 / USP6* / P35125* / ubiquitin specific peptidase 6*ENSMUSG0000000080420
Usp15 / Q8R5H1 / ubiquitin specific peptidase 15 / Q9Y4E8*ENSMUSG0000002012420
Usp11 / Q99K46 / ubiquitin specific peptidase 11 / P51784*ENSMUSG0000003106619
Usp31 / ubiquitin specific peptidase 31 / Q70CQ4*ENSMUSG0000006331716
Usp43 / Q8BUM9 / ubiquitin specific peptidase 43 / Q70EL4*ENSMUSG0000002090515


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR002893  Zinc finger, MYND-type
 IPR007052  CS domain
 IPR008978  HSP20-like chaperone
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway ISS
 biological_processGO:0031647 regulation of protein stability ISS
 biological_processGO:0034976 response to endoplasmic reticulum stress ISS
 biological_processGO:0048642 negative regulation of skeletal muscle tissue development IMP
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0071108 protein K48-linked deubiquitination IDA
 biological_processGO:0090068 positive regulation of cell cycle process ISS
 biological_processGO:1900037 regulation of cellular response to hypoxia ISO
 biological_processGO:1901799 negative regulation of proteasomal protein catabolic process IDA
 biological_processGO:1904292 regulation of ERAD pathway ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IMP
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding ISO
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity IDA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0004064 resistance to induced muscular atrophy "less than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041528 Q5XPI3 / Rnf123 / ring finger protein 123 / Q5XPI4*  / complex
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / complex / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction






 

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