ENSMUSG00000031066


Mus musculus

Features
Gene ID: ENSMUSG00000031066
  
Biological name :Usp11
  
Synonyms : Q99K46 / ubiquitin specific peptidase 11 / Usp11
  
Possible biological names infered from orthology : P51784
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.3
Gene start: 20703906
Gene end: 20720539
  
Corresponding Affymetrix probe sets: 10598933 (MoGene1.0st)   1426539_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033383
NCBI entrez gene - 236733     See in Manteia.
MGI - MGI:2384312
RefSeq - XM_017318470
RefSeq - NM_001358931
RefSeq - NM_145628
RefSeq - XM_006527622
RefSeq - XM_017318468
RefSeq - XM_017318469
RefSeq Peptide - NP_663603
RefSeq Peptide - NP_001345860
swissprot - Q99K46
Ensembl - ENSMUSG00000031066
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp11ENSDARG00000076303Danio rerio
 USP11ENSG00000102226Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp4 / P35123 / ubiquitin specific peptidase 4 (proto-oncogene) / Q13107* / ubiquitin specific peptidase 4*ENSMUSG0000003261247
Usp15 / Q8R5H1 / ubiquitin specific peptidase 15 / Q9Y4E8*ENSMUSG0000002012446
Usp32 / ubiquitin specific peptidase 32 / USP6* / P35125* / ubiquitin specific peptidase 6*ENSMUSG0000000080431
Usp19 / Q3UJD6 / ubiquitin specific peptidase 19 / O94966*ENSMUSG0000000667628
Usp31 / ubiquitin specific peptidase 31 / Q70CQ4*ENSMUSG0000006331720
Usp43 / Q8BUM9 / ubiquitin specific peptidase 43 / Q70EL4*ENSMUSG0000002090519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028134  Ubiquitin carboxyl-terminal hydrolase USP4
 IPR028135  Ubiquitin-like domain, USP-type
 IPR028889  Ubiquitin specific protease domain
 IPR035927  DUSP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / complex






 

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