ENSMUSG00000020124


Mus musculus

Features
Gene ID: ENSMUSG00000020124
  
Biological name :Usp15
  
Synonyms : Q8R5H1 / ubiquitin specific peptidase 15 / Usp15
  
Possible biological names infered from orthology : Q9Y4E8
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 123105006
Gene end: 123196995
  
Corresponding Affymetrix probe sets: 10372965 (MoGene1.0st)   1436891_at (Mouse Genome 430 2.0 Array)   1442307_at (Mouse Genome 430 2.0 Array)   1446186_at (Mouse Genome 430 2.0 Array)   1447881_x_at (Mouse Genome 430 2.0 Array)   1454036_a_at (Mouse Genome 430 2.0 Array)   1455842_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020334
Ensembl peptide - ENSMUSP00000151244
Ensembl peptide - ENSMUSP00000152028
NCBI entrez gene - 14479     See in Manteia.
MGI - MGI:101857
RefSeq - XM_006513227
RefSeq - NM_001301628
RefSeq - NM_027604
RefSeq - XM_006513225
RefSeq - XM_006513226
RefSeq Peptide - NP_001288557
RefSeq Peptide - NP_081880
swissprot - Q8R5H1
swissprot - A0A1W2P8B7
Ensembl - ENSMUSG00000020124
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP15ENSGALG00000030024Gallus gallus
 USP15ENSG00000135655Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp4 / P35123 / ubiquitin specific peptidase 4 (proto-oncogene) / Q13107* / ubiquitin specific peptidase 4*ENSMUSG0000003261257
Usp11 / Q99K46 / ubiquitin specific peptidase 11 / P51784*ENSMUSG0000003106644
Usp32 / ubiquitin specific peptidase 32 / USP6* / P35125* / ubiquitin specific peptidase 6*ENSMUSG0000000080430
Usp19 / Q3UJD6 / ubiquitin specific peptidase 19 / O94966*ENSMUSG0000000667628
Usp31 / ubiquitin specific peptidase 31 / Q70CQ4*ENSMUSG0000006331721
Usp43 / Q8BUM9 / ubiquitin specific peptidase 43 / Q70EL4*ENSMUSG0000002090519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR013792  RNA 3"-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028134  Ubiquitin carboxyl-terminal hydrolase USP4
 IPR028135  Ubiquitin-like domain, USP-type
 IPR028889  Ubiquitin specific protease domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR029346  Ubiquitin carboxyl-terminal hydrolase, C-terminal
 IPR035927  DUSP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISS
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0030509 BMP signaling pathway ISS
 biological_processGO:0035520 monoubiquitinated protein deubiquitination ISO
 biological_processGO:0035616 histone H2B conserved C-terminal lysine deubiquitination ISO
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation ISS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity ISS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046332 SMAD binding ISO
 molecular_functionGO:0061649 ubiquitin modification-dependent histone binding ISO


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Usp15tm1Pgrs/Usp15tm1Pgrs
Genetic Background: Not Specified

Allelic Composition: Usp15L749R/Usp15tm1Pgrs
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010751 decreased susceptibility to parasitic infection induced morbidity/mortality "decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Usp15tm1Pgrs/Usp15tm1Pgrs
Genetic Background: Not Specified

Allelic Composition: Usp15L749R/Usp15tm1Pgrs
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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