ENSMUSG00000032612


Mus musculus

Features
Gene ID: ENSMUSG00000032612
  
Biological name :Usp4
  
Synonyms : P35123 / ubiquitin specific peptidase 4 (proto-oncogene) / Usp4
  
Possible biological names infered from orthology : Q13107 / ubiquitin specific peptidase 4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 108347853
Gene end: 108392545
  
Corresponding Affymetrix probe sets: 10588903 (MoGene1.0st)   1442319_at (Mouse Genome 430 2.0 Array)   1450892_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141321
Ensembl peptide - ENSMUSP00000141612
Ensembl peptide - ENSMUSP00000141411
Ensembl peptide - ENSMUSP00000141368
Ensembl peptide - ENSMUSP00000035237
NCBI entrez gene - 22258     See in Manteia.
MGI - MGI:98905
RefSeq - XM_006511696
RefSeq - XM_006511700
RefSeq - XM_006511699
RefSeq - XM_006511697
RefSeq - NM_001311157
RefSeq - NM_011678
RefSeq Peptide - NP_001298086
RefSeq Peptide - NP_035808
swissprot - P35123
swissprot - A0A0A6YWM7
swissprot - A0A0A6YVY7
swissprot - A0A0A6YW28
swissprot - A0A0A6YW63
Ensembl - ENSMUSG00000032612
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp4ENSDARG00000014770Danio rerio
 USP4ENSGALG00000003799Gallus gallus
 USP4ENSG00000114316Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp15 / Q8R5H1 / ubiquitin specific peptidase 15 / Q9Y4E8*ENSMUSG0000002012458
Usp11 / Q99K46 / ubiquitin specific peptidase 11 / P51784*ENSMUSG0000003106645
Usp32 / ubiquitin specific peptidase 32 / USP6* / P35125* / ubiquitin specific peptidase 6*ENSMUSG0000000080431
Usp19 / Q3UJD6 / ubiquitin specific peptidase 19 / O94966*ENSMUSG0000000667629
Usp31 / ubiquitin specific peptidase 31 / Q70CQ4*ENSMUSG0000006331722
Usp43 / Q8BUM9 / ubiquitin specific peptidase 43 / Q70EL4*ENSMUSG0000002090520


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028134  Ubiquitin carboxyl-terminal hydrolase USP4
 IPR028135  Ubiquitin-like domain, USP-type
 IPR028889  Ubiquitin specific protease domain
 IPR035927  DUSP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000244 spliceosomal tri-snRNP complex assembly IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0034394 protein localization to cell surface IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031685 adenosine receptor binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: B6.129S1-Tlr3tm1Flv

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: B6.129S1-Tlr3tm1Flv

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: B6.129S1-Tlr3tm1Flv

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: B6.129S1-Tlr3tm1Flv

 MP:0009322 increased splenocyte apoptosis "increase in the number of spleen cells undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: B6.129S1-Tlr3tm1Flv

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: B6.129S1-Tlr3tm1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000032612 Usp4 / P35123 / ubiquitin specific peptidase 4 (proto-oncogene) / Q13107* / ubiquitin specific peptidase 4*  / reaction






 

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