ENSG00000135655


Homo sapiens

Features
Gene ID: ENSG00000135655
  
Biological name :USP15
  
Synonyms : Q9Y4E8 / ubiquitin specific peptidase 15 / USP15
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q14.1
Gene start: 62260338
Gene end: 62417431
  
Corresponding Affymetrix probe sets: 209475_at (Human Genome U133 Plus 2.0 Array)   210681_s_at (Human Genome U133 Plus 2.0 Array)   231990_at (Human Genome U133 Plus 2.0 Array)   244028_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449563
Ensembl peptide - ENSP00000448372
Ensembl peptide - ENSP00000448393
Ensembl peptide - ENSP00000258123
Ensembl peptide - ENSP00000280377
Ensembl peptide - ENSP00000309240
Ensembl peptide - ENSP00000446559
Ensembl peptide - ENSP00000446843
Ensembl peptide - ENSP00000447367
Ensembl peptide - ENSP00000447603
NCBI entrez gene - 9958     See in Manteia.
OMIM - 604731
RefSeq - XM_017020285
RefSeq - NM_001252078
RefSeq - NM_001252079
RefSeq - NM_006313
RefSeq - XM_005269261
RefSeq - XM_006719718
RefSeq - XM_017020284
RefSeq Peptide - NP_001239008
RefSeq Peptide - NP_001239007
RefSeq Peptide - NP_006304
swissprot - F8VZG8
swissprot - F8W0H4
swissprot - H0YH96
swissprot - H0YHM4
swissprot - H0YI26
swissprot - H0YI31
swissprot - Q9Y4E8
swissprot - F8VVY7
Ensembl - ENSG00000135655
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP15ENSGALG00000030024Gallus gallus
 Usp15ENSMUSG00000020124Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP4 / Q13107 / ubiquitin specific peptidase 4ENSG0000011431658
USP11 / P51784 / ubiquitin specific peptidase 11ENSG0000010222644
USP32 / Q8NFA0 / ubiquitin specific peptidase 32ENSG0000017083231
USP19 / O94966 / ubiquitin specific peptidase 19ENSG0000017204628
USP6 / P35125 / ubiquitin specific peptidase 6ENSG0000012920426
USP31 / Q70CQ4 / ubiquitin specific peptidase 31ENSG0000010340421
USP43 / Q70EL4 / ubiquitin specific peptidase 43ENSG0000015491419


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR013792  RNA 3"-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028134  Ubiquitin carboxyl-terminal hydrolase USP4
 IPR028135  Ubiquitin-like domain, USP-type
 IPR028889  Ubiquitin specific protease domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR029346  Ubiquitin carboxyl-terminal hydrolase, C-terminal
 IPR035927  DUSP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0035520 monoubiquitinated protein deubiquitination IDA
 biological_processGO:0035616 histone H2B conserved C-terminal lysine deubiquitination IDA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IMP
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity TAS
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0061649 ubiquitin modification-dependent histone binding IDA


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling
UCH proteinases
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / complex / reaction
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / complex / reaction
 ENSG00000106799 P36897 / TGFBR1 / transforming growth factor beta receptor 1  / reaction / complex
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / complex / reaction






 

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