ENSDARG00000004132


Danio rerio

Features
Gene ID: ENSDARG00000004132
  
Biological name :usp19
  
Synonyms : ubiquitin specific peptidase 19 / usp19
  
Possible biological names infered from orthology : O94966 / Q3UJD6
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 20145300
Gene end: 20177527
  
Corresponding Affymetrix probe sets: Dr.1751.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000116060
Ensembl peptide - ENSDARP00000157435
Ensembl peptide - ENSDARP00000116724
Ensembl peptide - ENSDARP00000100933
NCBI entrez gene - 324335     See in Manteia.
RefSeq - XM_005162118
RefSeq - XM_005162119
swissprot - B7ZDA9
swissprot - B7ZDA8
swissprot - F1RCS0
ZFIN ID - ZDB-GENE-030131-3055
Ensembl - ENSDARG00000004132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP19ENSGALG00000006824Gallus gallus
 USP19ENSG00000172046Homo sapiens
 Usp19ENSMUSG00000006676Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
usp11 / ubiquitin specific peptidase 11 / P51784* / Q99K46*ENSDARG0000007630318
usp4 / ubiquitin specific peptidase 4 (proto-oncogene) / P35123* / Q13107* / ubiquitin specific peptidase 4*ENSDARG0000001477018
usp32 / ubiquitin specific peptidase 32 / USP6* / Q8NFA0* / P35125* / ubiquitin specific peptidase 6*ENSDARG0000006189516
usp31 / ubiquitin specific peptidase 31 / Q70CQ4*ENSDARG0000007401714
usp43a / ubiquitin specific peptidase 43a / USP43* / Q70EL4* / Q8BUM9* / ubiquitin specific peptidase 43*ENSDARG0000010349414
usp43b / ubiquitin specific peptidase 43b / USP43* / Q70EL4* / Q8BUM9* / ubiquitin specific peptidase 43*ENSDARG0000008807213


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR002893  Zinc finger, MYND-type
 IPR007052  CS domain
 IPR008978  HSP20-like chaperone
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0021551 central nervous system morphogenesis IMP
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000135 notochord notochord decreased length , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001117 post-vent region post-vent region curled , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000034293 hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction / complex
 ENSDARG00000006181 hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction / complex
 ENSDARG00000044619 birc2 / baculoviral IAP repeat containing 2 / BIRC3* / Q13489* / Q13490* / Q62210* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / reaction / complex






 

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